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Advancing Methods for Biomolecular Crystallography
Author
Title
Advancing Methods for Biomolecular Crystallography [electronic resource] / edited by Randy Read, Alexandre G. Urzhumtsev, Vladimir Y. Lunin.
ISBN
9789400762329
Published
Dordrecht : Springer Netherlands : Imprint: Springer, 2013.
Physical Description
XIII, 362 p. 131 illus. digital.
Local Notes
Access is available to the Yale community.
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Summary
This work presents a snapshot of the state of the art of modern biomolecular crystallography, from crystallisation through structure determination and even interactive presentation on the web. Methods driving the latest automated structure determination pipelines are explained, as well as how to deal with problems such as crystal pathologies that still demand expert analysis. These methods are illustrated through their application to problems of great biological interest, such as the molecular machinery underlying the complement pathway, the mechanism of action of monoamine oxidase inhibitors, and the structure of the eukaryotic ribosome. Complementary approaches, such as neutron diffraction, small angle X-ray scattering, coherent diffraction and computational modelling, are also explored.
Variant and related titles
Springer ebooks.
Other formats
Printed edition:
Format
Books / Online
Language
English
Added to Catalog
May 22, 2013
Series
NATO Science for Peace and Security Series A: Chemistry and Biology,
Contents
The Zen of Model Anomalies – Correct most of them. Treasure the meaningful valid few. Live serenely with the rest!
Total Chemical Protein Synthesis for the Determination of Novel X-Ray Structures by Racemic Protein Crystallography
Crystal Pathologies
Crystallizing Membrane Proteins for Structure-Function Studies Using Lipidic Mesophases
Searching for needles in haystacks: Automation and the task of Crystal Structure determination
Data processing: how good are my data really?
Radiation Damage in Macromolecular Crystallography: what is it and why do we care?
Elemental analysis of proteins by Proton Induced X-ray Emission (microPIXE)
X-rays-induced cooperative atomic movement in a protein crystal
Everything happens at once – Deconvolving systematic effects in X-ray data processing
Extending the reach of molecular replacement
Phasing through location of small fragments and density modification with ARCIMBOLDO
SAD/MAD phasing
Macromolecular Phasing: Solving the Substructure
Advanced Applications of Shelxd and Shelxe.- Use of a weak anomalous signal for phasing in protein crystallography: Reflection from personal experience
Ab initio low resolution phasing
Model-building and Reduction of Model Bias in Electron Density Maps
Using Coot to Model Protein and Ligand Structures using X-ray data
Crystallographic Structure Refinement in a Nutshell
Crystallographic maps and models at low and at subatomic resolutions
Recent Advances in Low Resolution Refinement Tools in REFMAC
High resolution macromolecular crystallography
Publishing in Proteopedia: The Guide
Proteolysis, complex formation and conformational changes drive the complement pathways
Monoamine Oxidase Inhibitors: Diverse and Surprising Chemistry with expanding Pharmacological Potential
Structure of the eukaryotic ribosome: tips and tricks
Neutron Protein Crystallography. How to proceed the experiments to obtain the structural information of hydrogen, protons and hydration in Bio-macromolecules
Coherent diffraction and holographic imaging of individual biomolecules using low-energy electrons.- Structure analysis of biological macromolecules by small-angle X-ray scattering
Protein structure modeling with Rosetta: Case studies in structure prediction and enzyme repurposing.
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