Use of the maximum tolerated dose in animal bioassays for carcinogenicity
Introduction
Correlations between carcinogenic potency and other measures of toxicity
Advantages and disadvantages of bioassays that use the MTD
Options considered
Conclusions and recommendations
Two-stage model of carcinogenesis
Issues in risk assessment
Paradigm for ecological risk assessment
Introduction
Scope of ecological risk assessment
Revision of 1983 framework to incorporate ecological risk assessment
Key scientific problems limiting application of ecological risk assessment
Conclusions
Recommendations.