Animated audio-visual presentation with synchronized narration.

Title from title frames.

Gene transfer and gene therapy,

Mode of access: World Wide Web.

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Contents: Properties of retroviral vectors: Genetic stability in target cells, Transgene expression, Fidelity of replication, Target cell spectrum, Transdution efficiency, Toxicity, RCR or WT virus contamination, Integration, Immunogenicity

Innate immune recognition of retroviral vectors

Lentiviral vectors

Nuclear import of viral genome

Challenges of developing lentiviral vectors

Viral vector design

Design of HIV-based vectors

Third generation lentiviral vectors

Lentiviral vector composition

Lentiviral gene transfer

Reducing HIV content of packaging system

Self-inactivating transfer vectors

HIV vector transcription in HIV-1 infected cells

Lentiviral vector biosafety

Lentiviral vectors: risk of insertional mutagenesis.

Genetic vectors > genetics.

Genetic vectors > toxicity.

Lentiviruses > genetics.

Retroviruses > Genetics.

Gene Transfer Techniques.

Genetic Therapy - methods.

Genetics, Medical.

Genome, Viral.

HIV-1.

Mutagenesis, Insertional.

Virus Integration - genetics.