Animated audio-visual presentation with synchronized narration.

Title from title frames.

Pain and the control of pain : pain transmission, regulation and management,

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Contents: Opioid receptors: relevance

Opioids in pain management

Opioid analgesics: pharmacology

The endogenous opioid system

Endogenous opioid peptides

Effector systems

Opioid receptor activation

Opioid receptor mediated effects

Opioid receptor polymorphisms

Dimerization

Internalization

Endogenous opioids and opioid receptors are located at peripheral, spinal and supraspinal sites

Opioid analgesia

Cell transfection with a viral vector

Viral vectors expressing endogenous opioid precursors

Drugs that activate opioid receptors

Opioid administration

Paradoxical pain and tolerance

Opioid-induced hyperalgesia: paradoxical pain

Tolerance

Peripheral opioid antagonists

Clinical use of opioids

Opioids in pain management

Principle for safe and effective opioid use.

Pain > drug therapy.

Pain > prevention & control.

Pain > therapy.