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Viruses, Genes, and Cancer
Title
Viruses, Genes, and Cancer [electronic resource] / edited by Eric Hunter, Klaus Bister.
ISBN
9783319618043
Publication
Cham : Springer International Publishing : Imprint: Springer, 2017.
Physical Description
XIII, 221 p. : online resource.
Local Notes
Access is available to the Yale community.
Access and use
Access restricted by licensing agreement.
Summary
This volume focuses on virus-host cell interactions, cellular genes acquired or modulated by viruses, the pathological effects of these interactions, and therapeutic interventions. Several chapters specifically address the role of viruses and genes – such as oncogenes, proto-oncogenes, or tumor suppressor genes – in the etiology of human cancer. Oncogenic signaling by PI3 kinase, mTOR, Akt, or the major cancer drivers MYC and RAF, and the role of tumor suppressors like p53, are discussed in detail. The volume also explores the emerging role of noncoding RNAs such as microRNAs in tumorigenesis and cancer therapeutics, and offers new insights into the role of HIV-host interactions relevant to pathogenesis and treatment. Gathering contributions written by leading scientists in their respective fields, the volume offers a valuable resource for researchers and clinicians alike.
Variant and related titles
Springer ebooks.
Other formats
Printed edition:
Format
Books / Online
Language
English
Added to Catalog
September 05, 2017
Series
Current Topics in Microbiology and Immunology, 407
Contents
Exchange of Genetic Sequences Between Viruses and Host
Virus-Host Gene Interactions that Define HIV Disease Progression
Sequencing the Biology of Entry: The Retroviral env Gene
Infectious Agents in Bovine Red Meat and Milk and Their Potential Role in Cancer and Other Chronic Diseases
MYC and RAF: Key Effectors in Cellular Signaling and Major Drivers in Human Cancer
Oncogenic Roles of the PI3K/AKT/mTOR Axis
MicroRNAs and Cancer
The Evolution of Tumor Formation in Humans and Mice with Inherited Mutations in the P53 Gene.
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