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Breast Cancer Innovations in Research and Management
Title
Breast Cancer [electronic resource] : Innovations in Research and Management / edited by Umberto Veronesi, Aron Goldhirsch, Paolo Veronesi, Oreste Davide Gentilini, Maria Cristina Leonardi.
ISBN
9783319488486
Publication
Cham : Springer International Publishing : Imprint: Springer, 2017.
Physical Description
XIV, 928 p. 296 illus., 236 illus. in color : online resource.
Local Notes
Access is available to the Yale community.
Access and use
Access restricted by licensing agreement.
Summary
This book provides the reader with up-to-date information on important advances in the understanding of breast cancer and innovative approaches to its management. Current and emerging perspectives on genetics, biology, and prevention are first discussed in depth, and individual sections are then devoted to pathology, imaging, oncological surgery, plastic and reconstructive surgery, medical oncology, and radiotherapy. In each case the focus is on the most recent progress and/or state of the art therapies and techniques. Further topics to receive detailed consideration include particular conditions requiring multidisciplinary approaches, the investigation of new drugs and immunological agents, lifestyle and psychological aspects, and biostatistics and informatics. The book will be an excellent reference for practitioners, interns and residents in medical oncology, oncologic surgery, radiotherapy, pathology, and human genetics, researchers, and advanced medical students.
Variant and related titles
Springer ebooks.
Other formats
Printed edition:
Format
Books / Online
Language
English
Added to Catalog
December 01, 2017
Contents
Part I An Integrated view of Breast Cancer Biology.- Fundamental pathways in breast cancer 1: signaling from the membrane
Fundamental pathways in breast cancer 2: maintenance of genomic stability.-Fundamental pathways in breast cancer 3: estrogen biology
Fundamental pathways in breast cancer 4: maintenance of epigenomic stability and the role of stem cells
Breast cancer microenvironment and the metastatic process
Mouse models of breast cancer.- Human mammary tumor virus proteins in human breast cancer cells
Part II Epidemiology, Genetics and Prevention
Epidemiology, life style and environment
Genetic predisposition
Chemoprevention
Surgical prevention
Part III Pathology: Standard and Molecular Diagnostics
Premalignant lesions
Prognostic and predictive role of genetic signatures
Adding molecular information to immunohistochemistry
Special types of breast cancer and nonepithelial tumors
Pathology after neoadjuvant treatments
Breast cancer genomics
Pathology report 2015
Part IV Imaging
Radiological screening of breast cancer. Evolution
Innovation of radiological means for breast cancer
Nuclear medicine in the clinical management (ROLL, SNB and PET)
One-step systemic staging for patients with breast cancer
Imaging after breast surgery
Integrated breast biopsy for best radiological diagnosis of breast cancer
Part V Oncological Surgery
Conservative surgery
Conservative mastectomies
Surgical treatment of reappearance of breast cancer
Management of the axilla
Management of intraepithelial disease
Surgery after neoadjuvant therapies
Surgery of primary tumor in stage IV breast cancers
Local therapy for breast cancer in malignant lymphoma survivors
Surgery of metastases
Part VI Plastic and Reconstructive Surgery
Oncoplastic surgery
Delayed breast reconstruction
Immediate breast reconstruction direct-to-implant
Breast reconstruction with tissue expanders and definitive implant replacement
Breast reconstruction with pedicled flaps
Breast reconstruction with free flaps
Contralateral breast management
Fat grafting in breast reconstruction
Breast reconstruction with biological and nonbiological meshes
How to manage complications in breast reconstruction
Part VII Medical Oncology
Adjuvant systemic therapies by subtypes: guidelines
Primary systemic therapies: guidelines
Treatment of advanced disease: guidelines
Endocrine therapies in the adjuvant and advanced disease settings
Chemotherapy regimens in the adjuvant and advanced disease settings
Anti-HER2 therapies in the adjuvant and advanced disease settings
Systemic therapy with bisphosphonates and anti-RANK-L agents
Systemic treatment for specific medical situations
Part VIII Radiotherapy
Conceptual basis and principles of radiation oncology
Whole breast radiation following breast-conserving surgery in invasive cancer
Whole breast radiation following breast-conserving surgery in noninvasive cancer
Post-mastectomy radiotherapy
Integration of radiotherapy with systemic therapies
Partial breast irradiation
Intraoperative radiotherapy ELIOT
Radiotherapy for metastatic lesions
Part IX Special Conditions Requiring Multidisciplinary Approaches
Emergencies in breast cancer
Breast cancer during pregnancy
Fertility issues in patients with newly diagnosed breast cancer
Sexual functions and breast cancer
Male breast cancer
Inflammatory breast cancer
Treatment of CNS involvement
Treatment of skeletal disease
Follow-up of patients with breast cancer
Part X Investigating New Drugs and Immunological Agents in Breast Cancer
Targeting immune-checkpoint
Targeting PIK3CA/AKT/mTOR
Targeting genome instability and DNA repair
Targeting CDK4/6 pathway
Targeting FGFR pathway
Integrating next generation sequencing data in trial design
Part XI Investigational and Miscellaneous Approaches
Lifestyle and breast cancer
Psychological support
HIFU and radiofrequency as alternatives to surgery
Hyperthermia with RT and with systemic therapies
Electro-chemotherapy
Circulating miRNA in early diagnosis
Relevance of stem cells
Part XII Biostatistics and Bioinformatics
Subgroup analyses and information from clinical trials on breast cancer
The methodology of meta analyses and its potential contribution to patient care
Modern biostatistics for accelerated data acquisition for new drugs
Bioinformatics for clinical use in breast cancer
Efficacy endpoints in breast cancer studies.
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