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Nuclear-Cytoplasmic Transport
Title
Nuclear-Cytoplasmic Transport [electronic resource] / edited by Weidong Yang.
ISBN
9783319773094
Publication
Cham : Springer International Publishing : Imprint: Springer, 2018.
Physical Description
VI, 274 p. 44 illus., 40 illus. in color : online resource.
Local Notes
Access is available to the Yale community.
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Access restricted by licensing agreement.
Summary
Dysfunction of nuclear-cytoplasmic transport systems has been associated with many human diseases. Thus, understanding of how functional this transport system maintains, or through dysfunction fails to maintain remains the core question in cell biology. In eukaryotic cells, the nuclear envelope (NE) separates the genetic transcription in the nucleus from the translational machinery in the cytoplasm. Thousands of nuclear pore complexes (NPCs) embedded on the NE selectively mediate the bidirectional trafficking of macromolecules such as RNAs and proteins between these two cellular compartments. In this book, the authors integrate recent progress on the structure of NPC and the mechanism of nuclear-cytoplasmic transport system in vitro and in vivo.
Variant and related titles
Springer ebooks.
Other formats
Printed edition:
Format
Books / Online
Language
English
Added to Catalog
August 01, 2018
Series
Nucleic Acids and Molecular Biology, 33
Contents
Assembly of the nuclear pore complex
Structure of Yeast nuclear pore complexes
Structure and function of nucleoporins in nuclear transport
Dynamic structures of the nuclear pore complex and their roles in nucleo-cytoplasmic transport
Non-canonical roles of nuclear pore proteins
On the role of the channel nucleoporins in nuclear transport
Structures of Importins and Exportins
Navigating the Nuclear Envelope: one or multiple transport mechanisms for integral membrane proteins?
mRNA export and its dysregulation in disease
Coarse-grained molecular dynamics of the natively-unfolded domain of the NPC
On the effects of leukemogenic nucleoporin fusion proteins on nucleocytoplasmic transport and gene expression
Structure and Function of the Nuclear Pore Complex Revealed by Advanced Fluorescence Microscopy.
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