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Histamine Receptors as Drug Targets
Title
Histamine Receptors as Drug Targets [electronic resource] / edited by Ekaterini Tiligada, Madeleine Ennis.
ISBN
9781493968435
Publication
New York, NY : Springer New York : Imprint: Humana Press, 2017.
Physical Description
1 online resource (XVI, 517 p.) 138 illus., 93 illus. in color.
Local Notes
Access is available to the Yale community.
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Access restricted by licensing agreement.
Summary
This book illustrates the current state-of-the-art in histamine research, with a focus on the appropriate methodologies to investigate the pharmacological properties and the therapeutic exploitation of HRs and their ligands. In addition, the range of techniques described provides an introduction to complementary cross-methodological disciplines beyond these fields. This multi-disciplinary approach is required to define the ‘decision gates’ that determine the development of more effective and safer therapeutic options for many forms of highly prevalent and debilitating diseases, such as asthma, dementias, dermatitis, and arthritis. Written for the Methods in Pharmacology and Toxicology series, chapters concentrate on practical, hands-on protocols from experts in the techniques. Authoritative and thorough, Histamine Receptors as Drug Targets seeks to aid pharmacologists, biochemists, drug discovery researchers, molecular biologists, chemists, toxicologists, lab scientists, medical doctors, principle investigators, research scientists, lab directors and technicians, as well as graduate students around the world in pursuing the study of this vital scientific area.
Variant and related titles
Springer protocols (Series)
Other formats
Printed edition:
Format
Books / Online
Language
English
Added to Catalog
August 31, 2018
Series
Methods in Pharmacology and Toxicology,
Contents
Methodologies to Identify and Analyze Genetic Polymorphisms for Human Histamine Receptors
Development, Characterization, and Validation of Anti-Human H3 Receptor Isoform-Specific Antibodies
Approaches to Recombinant Histamine H3/H4 Receptor Expression in Mammalian Cells
Histamine H2 Receptor Biased Signaling Methods
Ligand-Binding Kinetics on Histamine Receptors
Methods to Study the Molecular Pharmacology of the Histamine H4 Receptor
Chemiluminescence: A Sensitive Method for Detecting the Effects of Histamine Receptor Agonists/Antagonists on Neutrophil Oxidative Burst
Techniques Used in Pharmacological Evaluation of Histamine H4 Receptor Function on Native Human Eosinophils
Assessment of the Efficacy of Histamine Receptor Antagonists in Murine Models of Atopic Dermatitis
Methodological Approaches to Study Histamine Pharmacology in the Kidney: From Cell Culture and Cell Imaging to Functional Assays and Electron Microscopy
Histamine and the Kidney: In Vivo Animal Models
Methodological Approaches to Investigate the Effects of Histamine Receptor Targeting Compounds in Preclinical Models of Breast Cancer
Evaluation of Histidine Decarboxylase (HDC) Activity and Human Histamine Receptor 3 (H3R) and HDC mRNA Levels
Cerebrospinal Fluid Markers in Neuroinflammation: The Paradigm of Optic Neuritis
In Vivo Diagnostic Procedures for IgE-Mediated Allergic Disorders
Dermatological Indications of Antihistamines
Histamine Quantification in Human Blood Samples.
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