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Genetic Epidemiology Methods and Protocols
Title
Genetic Epidemiology [electronic resource] : Methods and Protocols / edited by Evangelos Evangelou.
ISBN
9781493978687
Publication
New York, NY : Springer New York : Imprint: Humana Press, 2018.
Physical Description
1 online resource (X, 299 p.) 35 illus., 23 illus. in color.
Local Notes
Access is available to the Yale community.
Access and use
Access restricted by licensing agreement.
Summary
This volume details fast-moving research while providing in-depth descriptions of methods and analytical approaches that are helping to understand the genome and how it is related to complex diseases. Chapters guide the reader through common and rare variation, gene-gene and gene-environment interactions and state-of-the-art approaches for the synthesis of genome-wide and gene expression data. Novel approaches for associations in the HLA region, family-based designs, Mendelian Randomization and Copy Number Variation are also presented. The volume concludes with the challenges researchers face while moving from identifying variants to their functional role and potential drug targets. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, a thorough presentation of methods and approaches and tips on troubleshooting and avoiding known pitfalls.
Variant and related titles
Springer protocols (Series)
Other formats
Printed edition:
Format
Books / Online
Language
English
Added to Catalog
August 31, 2018
Series
Methods in Molecular Biology, 1793
Contents
Introduction to Epidemiological Studies
Key Concepts in Genetic Epidemiology
Quality Control of Common and Rare Variants
Genome Wide Association Studies
Assessing Rare Variation in Complex Traits
Meta-analysis of Common and Rare Variants
Gene-gene and Gene-environment Interactions
Genetic Association in the HLA Region
Novel Methods for Family-based Genetic Studies
Methods for Polygenic Traits
Multivariate Methods for Meta-analysis of Genetic Association Studies
Methods of Analysis and Meta-Analysis for Identifying Differentially Expressed Genes
A Primer in Mendelian Randomization Methodology with a Focus on Utilizing Published Summary Association Data
Copy Number Variation
From Identification to Function: Current Strategies to Prioritise and Follow-Up GWAS Results
Translating Human Genetics into Novel Drug Targets.
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