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Transition Metal Complexes as Drugs and Chemotherapeutic Agents
Author
Title
Transition Metal Complexes as Drugs and Chemotherapeutic Agents [electronic resource] / by Nicholas Farrell.
ISBN
9789401175685
Publication
Dordrecht : Springer Netherlands, 1989.
Physical Description
1 online resource (304 p).
Local Notes
Access is available to the Yale community.
Access and use
Access restricted by licensing agreement.
Summary
When this book was first conceived as a project the expanding interest in the clinical use of platinum and gold complexes made a survey of the relevant biological properties of metal complexes timely and appropriate. This timeliness has not diminished during the gestation and final publica tion of the manuscript. The introduction contains an explanation of the layout and approach to the book, which I wrote as an overall survey of the wide variety of biological properties of metal complexes. Hopefully, the reader will see the parallels in mechanisms and behavior, even in different organisms. The writing was considerably helped by the enthusiasm and confidence (totally unearned on my part) in the project of Professor Brian James and lowe him my special thanks. I also owe a great debt of gratitude to my colleagues, and especially to Eucler Paniago, of the Universidade Federal de Minas Gerais, for their comprehension and for the initial leave of absence which allowed me to begin the project. To those who read some or all of the manuscript and made suggestions, Bernhard Lippert, Kirsten Skov, and Tom Tritton, as well as the editor's reviewer I am also grateful. As usual, the final responsibility for errors or otherwise rests with the author.
Variant and related titles
Springer ENIN.
Other formats
Printed edition:
Printed edition:
Printed edition:
Format
Books / Online
Language
English
Added to Catalog
September 11, 2018
Series
Catalysis by Metal Complexes, 11
Contents
Metals in Medicine
Chemotherapeutic Agents and Drugs
Mechanisms of Toxicity
Metal Accumulation and Activation
Biochemical Targets for Metal Complexes
Summary
References
1. Interaction of Metal Complexes with DNA
1.1. DNA and Conformation
1.2. Experimental Methods for the Study of Conformational Changes
1.3. Binding of Metal Complexes to DNA
1.4. Summary
References
2. Platinum—Amine Complexes as Anticancer Agents
2.1. The Discovery of Cisplatin as an Antitumour Agent
2.2. Clinical Properties of Cisplatin
2.3. Development of Cisplatin Analogues
2.4. Biochemical Mechanism of Action of Platinum Complexes
2.5. Summary
References
3. Structure—Activity Relationships of Platinum— Amine Complexes
3.1. The Requirement for Neutrality
3.2. Complexes of Pt(IV)
3.3. Nature of the Leaving Group
3.4. Nature of the Nonleaving Group
3.5. Novel and Targeted Approaches to [PtX2(am)2] Complexes
3.6. Quantitative Structure—Activity Relationships
3.7. Chemistry of Platinum—Amine Complexes
3.8. Summary
References
4. Interactions of Platinum Complexes with DNA Components
4.1. Structural Aspects of Metal—Nucleobase Binding
4.2. Reactivity of Platinum Metal—Base Complexes
4.3. Solid State Structural Studies
4.4. Structural Studies on Di- and Oligonucleotide Complexes
4.5. Platinum Adducts from DNA Degradation
4.6. On the Molecular Mechanism of Antitumour Action of Cisplatin
4.7. Summary
References
5. The Platinum—Pyrimidine Blues
5.1. Properties of the Platinum—Pyrimidine Blues
5.2. Platinum Blues not Derived from Pyrimidines
5.3. X-Ray Structure of Platinum—Pyrimidine and ?-Pyridone Blues
5.4. Formation of Platinum—Pyrimidine and ?-Pyridone Blues
5.5. Studies of Crystalline Blues
5.6. Biological Studies on Platinum—Pyrimidine Blue Precursors
5.7. Summary
References
6. Antitumour Activity of Metal Complexes
6.1. Platinum Group Metal Complexes
6.2. Copper Complexes
6.3. Silver and Gold
6.4. Organometallic Complexes
6.5. Summary
References
7. Metal-Mediated Antibiotic Action
7.1. Discovery and Pharmacology of Bleomycin
7.2. Structure of Bleomycin and Analogues
7.3. Metal Complexes of Bleomycin
7.4. Mechanism of Action of Bleomycin
7.5. Other Metal Binding Antibiotics
7.6. Summary
References
8. Metals, Metal Complexes, and Radiation
8.1. Interaction of Radiation and Biological Tissue
8.2. Chemical Modification of Radiation Damage
8.3. Metal Complexes as Radiation Sensitizers
8.4. Metal Complexes and Radioprotection
8.5. Activation of Metal Complexes
8.6. Summary
References
9. Antibacterial Effects of Metal Complexes
9.1. Mercury and Silver Salts as Antibacterial Agents
9.2. Antibacterial Activity of Chelating Agents and Metal Chelates
9.3. Antibacterial Activity of Metal—Amine Complexes
9.4. Redox Activity and Antibacterial Activity
9.5. Summary
References
10. Antiviral and Antiparasitic Effects of Metal Complexes
10.1. Antiviral Therapy
10.2. Chelating Agents and Metal Complexes as Antiviral Agents
10.3 Metal Complexes as Antiprotozoal Agents
10.4. Summary
References
11 Metal Complexes in Arthritis
11.1. Gold Complexes in the Treatment of Rheumatoid Arthritis
11.2. Copper in Arthritis
11.3. Other Metals
11.4. Summary
References
12. Miscellaneous Uses of Metal Complexes
12.1. Mercurial Diuretics
12.2. Neuromuscular Effects of Metal Complexes
12.3. Nitroprusside as Vasodilator
12.4. Summary
References
Names and Abbreviations
Glossary of Terms and Definitions
Appendix 1
Appendix 2
Index of Subjects.
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