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Muscarinic Receptor: From Structure to Animal Models
Title
Muscarinic Receptor: From Structure to Animal Models [electronic resource] / edited by Jaromir Myslivecek, Jan Jakubik.
ISBN
9781493928583
Edition
1st ed. 2016.
Publication
New York, NY : Springer New York : Imprint: Humana Press, 2016.
Physical Description
1 online resource (XII, 287 p.) 77 illus., 42 illus. in color.
Local Notes
Access is available to the Yale community.
Access and use
Access restricted by licensing agreement.
Summary
This volume provides methods for characterization of muscarinic receptor in crystallography studies that advanced our understanding of structural properties and activation mechanism of muscarinic receptors and are cornerstone in molecular modeling and computer‑based approaches to study muscarinic receptors. Muscarinic Receptor: From Structure to Animal Models guides readers through binding techniques, protocols to investigate molecular properties of muscarinic receptors, protocols to study muscarinic receptors in the central nervous system using autoradiography and PET studies, and protocols on animals with knock-out and knock-in muscarinic genes to study role of muscarinic receptors in physiology and behavior. Written in the popular Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your own laboratory. Concise and easy-to-use, Muscarinic Receptor: From Structure to Animal Models aims to ensure successful results in the further study of this vital field.
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Springer protocols (Series)
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Format
Books / Online
Language
English
Added to Catalog
January 16, 2019
Series
Neuromethods, 107
Contents
Towards the Crystal Structure Determination of Muscarinic Acetylcholine Receptors
Homology Modeling and Docking Evaluation of Human Muscarinic Acetylcholine Receptors
Radioligand Binding at Muscarinic Receptors
Binding Method for Detection of Muscarinic Acetylcholine Receptors in Receptor’s Natural Environment
Use of Antibodies in the Research on Muscarinic Receptor Subtypes
Allosteric Modulation of Muscarinic Receptors
Subcellular and Synaptic Localization of Muscarinic Receptors in Neurons Using High-Resolution Electron Microscopic Preembedding Immunogold Technique
Investigation of Muscarinic Receptors by Fluorescent Techniques
Autoradiography Assessment of Muscarinic Receptors in the Central Nervous System
Imaging of Muscarinic Receptors in the Central Nervous System
Detection of Non-Neuronal Acetylcholine
Utilization of Superfused Cerebral Slices in Probing Muscarinic Receptor Autoregulation of Acetylcholine Release
Regulation of Heart Contractility by M2 and M3 Muscarinic Receptors: Functional Studies using Muscarinic Receptor Knockout Mouse
Muscarinic Receptor Gene Transfections and In Vivo Dopamine Electrochemistry: Muscarinic Receptor Control of Dopamine-Dependent Reward and Locomotion.
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