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Tumors of the Central Nervous System, Volume 5 Astrocytomas, Hemangioblastomas, and Gangliogliomas
Title
Tumors of the Central Nervous System, Volume 5 [electronic resource] : Astrocytomas, Hemangioblastomas, and Gangliogliomas / edited by M.A. Hayat.
ISBN
9789400720190
Publication
Dordrecht : Springer Netherlands, 2012.
Physical Description
1 online resource (XXVI, 290 p).
Local Notes
Access is available to the Yale community.
Access and use
Access restricted by licensing agreement.
Summary
The most recent developments in diagnostic and therapeutic aspects of Gliomas (glioblastoma) in the brain are presented. The importance of personalized medicine and clinical validation for targeted therapy are discussed. The identification of various types of biomarkers (determined by molecular genetics) is included, along with their advantages and limitations as markers in tumor detection and diagnosis. The identification and validation of brain cancer (glioblastoma) genes are discussed. The role of cancer stem cells in the initiation and persistence of malignant gliomas is explained; response of glioblastoma cancer stem cells to various growth factors, such as epidermal growth factor receptor kinase inhibitor, is explained. The use of surgical resection, chemotherapy (e.g., temozolomide), immunotherapy, and radiation therapy for glioblastoma patients is included. Biological impediments for chemotherapy and radiotherapy for malignant glioblastoma are pointed out. Standard (established) as well as newer imaging modalities (proton magnetic resonance spectroscopy) are discussed. Also included are proton magnetic resonance spectroscopy in intracranial gliomas, and the use of proton magnetic spectroscopic imaging in determining the infiltration zone in gliomas. The role of molecular signaling in the CNS cancer development is explained, including cell death signaling in glioblastoma multiforme.
Variant and related titles
Springer ENIN.
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Format
Books / Online
Language
English
Added to Catalog
April 08, 2019
Series
Tumors of the Central Nervous System, 5
Contents
Introduction. Part 1. ASTROCYTOMAS. DIAGNOSIS AND BIOMARKERS
1. Methylation in malignant astrocytomas
2. Deciphering the function of doppel protein in astrocytomas
3. Astrocytic tumors: role of antiapoptotic proteins
4. Astrocytomas: role of wnt/β- catenin/tcf signaling pathway
5. Subependymal giant cell astrocytoma: role of mtor pathway
6. Role of progesterone preceptor isoforms in human astrocytomas growth
7. Astrocytic tumors: role of carbonic anhydrase ix
8. Development of cysts in pilocytic astrocytomas: role of eosinophilic granular bodies (method)
9. Role of synemin in astrocytoma cell migration
10. Diffuse astrocytomas: immunohistochemistry of mgmt expression.-11. Central nervous system germ cell tumors: an epidemiology review
12. Raf genes and mapk activation in pilocytic astrocytomas
13. Biomarker discovery in central nervous system neoplasms: past, present and future
14. Astrocytomas: role of taurine in apoptosis using magnetic resonance spectroscopy
15. Imaging of hypoxia-inducible factor-1-active regions in tumors using a pos and 123i-ibb method
16. Diffuse low-grade astrocytomas: p53-mediated inhibition of angiogenesis
17. Spontaneous regression of cerebellar astrocytomas mansoor foroughi, shibu pillai, and paul steenbok
18. Subependymal giant cell astrocytoma: gene expression profiling magdalena ewa tyburczy and bozena kaminska. THERAPY. - 19. Time- resolved laser induced fluorescence spectroscopy (trlifs): a tool for intra-operative diagnosis of brain tumors and maximizing extent of surgical resection
20. Magnetic resonance-guided laser interstitial thermal therapy for brain tumors
21. Nanotechnology-based therapy for malignant tumors of the central nervous system
22. Pilocytic astrocytoma: pthological and immunohistochemical factors affecting surgical treatment and surveillance
23. Pilomyxoid astrocytoma: chemotherapy hitoshi tsugu, shinya oshiro, fuminari komatsu, hiroshi abe, takeo fukushima, tooru inoue, fumio yanai, yuko nomura. PROGNOSIS
24. Astrocytomas: predicting survival and recurrence using cerebral blood volume measurements.-25. Electronic patient-reported outcome monitoring (eprom) in brain tumour patients. Part 2. HEMANGIOBLASTOMA
26. Intra-operative icg use in the management of hemangioblastomas
27. Hemangioblastoma cysts: diagnosis using fluorescence with 5-aminolevulinic acid
28. Hemangioblastoma-stereotactic radiosurgery anand veeravagu, bowen jiang, and steven chang. Part 3.GANGLIOGLIOMA
29. Gangliogliomas: molecular pathogenesis and epileptogenesis eleonora aronica and pitt niehusmann
30. Epilepsy-associated gangliogliomas: identification of genes with altered expression. Index.
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