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Drug Resistance in Leishmania Parasites Consequences, Molecular Mechanisms and Possible Treatments
Title
Drug Resistance in Leishmania Parasites [electronic resource] : Consequences, Molecular Mechanisms and Possible Treatments / edited by Alicia Ponte-Sucre, Emilia Diaz, Maritza Padrón-Nieves.
ISBN
9783709111253
Publication
Vienna : Springer Vienna : Imprint: Springer, 2013.
Physical Description
1 online resource (XIV, 462 p.)
Local Notes
Access is available to the Yale community.
Access and use
Access restricted by licensing agreement.
Summary
One of the main problems concerning therapeutic tools for the treatment of parasitic diseases, including leishmaniasis, is that some field parasites are naturally resistant to the classical drugs; additionally, current therapies may select parasites prone to be resistant to the applied drugs. These features are (at least partially) responsible for the disappointing persistence of the disease and resultant deaths worldwide. This book provides a comprehensive view of the pathology of the disease itself, and of parasitic drug resistance, its molecular basis, consequences and possible treatments. Scientists both from academic fields and from the industry involved in biomedical research and drug design, will find in this book a valuable and fundamental guide that conveys the knowledge needed to understand and to improve the success in combating this disease worldwide.
Variant and related titles
Springer ENIN.
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Format
Books / Online
Language
English
Added to Catalog
April 11, 2019
Contents
Foreword
Introduction. Leishmaniasis, the biology of a parasite. Alicia Ponte Sucre
I Determinant features in leishmaniasis
1 Molecular evolution and phylogeny of Leishmania. Gabriele Schoenian, Elisa Cupolillo, Isabel Mauricio
2 The role of reservoirs: Canine leishmaniasis. Lenea Campino, Carla Maia
3 Epidemiology of leishmaniasis in the time of drug resistance. Jean Claude Dujardin, Saskya Decuypere
II Leishmania and the immune system
4 The role of the immune system in resistance to infection. Lukasz Kedzierski, Krystal J. Evans
5 Vaccination as a control measure. Katrin Färber , Heidrun Moll
6 Leishmania vaccines: Past, Present and Future. Bhavana Sethu Lakshmi, Rentala Madhubala
III Challenges in the diagnosis, treatment and control of leishmaniasis in times of drug resistance
7 Co-infection with HIV. Margriet den Boer, Luis Rivas, Jorge Alvar
8 Visceral leishmaniasis. Shyam Sundar , J aya Chakravarty
9 American Tegumentary leishmaniasis. Olga Zerpa, Alicia Ponte-Sucre
IV Molecular features of drug-resistant Leishmania
10 Genetic expression and drug resistance, the role of proteomics. Patricia Cuervo, Jose Batista de Jesus
11 The role of ABC transporters in drug-resistant Leishmania. Adriano C Coelho, Paulo C Cotrim
12 Functional analysis of Leishmania membrane (non ABC) transporters involved in drug resistance. Scott M Landfear
13 Intracellular mechanisms of resistance in Leishmania
V Pharmacology and chemotherapy of leishmaniasis. Mitali Chatterjee
14 Classical vs new Treatment regimens. Louis Maes, Raquel Andreia Inocencio da Luz, Paul Cos, Vanessa Yardley
15 Drug targets, drug effectors and drug targeting and delivery. Philippe M Loiseau, Gillian Barratt
16 Mechanisms of miltefosine resistance in Leishmania. Francisco Gamarro, María P Sánchez-Cañete, Santiago Castanys
17 P-glycoprotein-like transporters in Leishmania: a search for reversal agents. Bruno Pradines
VI Strategies to circumvent drug resistance in Leishmania
18 The relevance of susceptibility tests, breakpoints and markers. Louis Maes, Paul Cos and Simon Croft
19 The Concept of Fitness and drug resistance in Leishmania. Alicia Ponte-Sucre, Emilia Diaz, Maritza Padrón-Nieves.
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