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Pharmacokinetic-Pharmacodynamic Modeling and Simulation
Author
Title
Pharmacokinetic-Pharmacodynamic Modeling and Simulation [electronic resource] / by Peter L. Bonate.
ISBN
9780387271996
Edition
1st ed. 2006.
Publication
New York, NY : Springer US : Imprint: Springer, 2006.
Physical Description
1 online resource (XII, 388 p.) 269 illus.
Local Notes
Access is available to the Yale community.
Access and use
Access restricted by licensing agreement.
Summary
This book presents both the art and science behind pharmacokinetic-pharmacodynamic modeling. Using a building-block approach, the author starts from linear and nonlinear models at the individual level and proceeds to develop more complex linear and nonlinear mixed effects models at the population level, with particular emphasis on showing the interrelationships between the various model types. The theory behind the methods are illustrated using real data drawn from the literature and from the author’s own experiences in drug development. Data are analyzed using a variety of software, including SAS, WinNonlin, SAAM II, and NONMEM. A key component of the book is to show how models are accepted and rejected, ultimately leading to a useful and informative model that can be utilized using computer simulation to answer "what-if" questions.
Variant and related titles
Springer ENIN.
Other formats
Printed edition:
Printed edition:
Printed edition:
Format
Books / Online
Language
English
Added to Catalog
June 24, 2019
Contents
The Art of Modeling
Linear Models and Regression
Nonlinear Models and Regression
Variance Models, Weighting, and Transformations
Case Studies in Linear and Nonlinear Modeling
Linear Mixed Effects Models
Nonlinear Mixed Effects Models: Theory
Nonlinear Mixed Effects Models: Practical Issues
Nonlinear Mixed Effects Models: Case Studies.
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