Strategic Use of Preclinical Pharmacokinetic Studies and In Vitro Models in Optimizing ADME Properties of Lead Compounds
Role of Mechanistic Transport Studies in Lead Optimization
Metabolic Activation-Role in Toxicity and Idiosyncratic Reactions
Case History — Use of ADME Studies for Optimization of Drug Candidates
Solubility, Solubilization and Dissolution in Drug Delivery During Lead Optimization
Lipid-based Systems, Drug Exposure and Lead Optimization
Biopharmaceutics Modeling and the Role of Dose and Formulation on Oral Exposure
Application of Physicochemical Data to Support Lead Optimization by Discovery Teams
Computational Models Supporting Lead Optimization in Drug Discovery
Prodrug Strategies for Improving Drug-Like Properties
The Application of Multivariate Data Analysis to Compound Property Optimization
Case History: Toxicology Biomarker Development Using Toxicogenomics
Predicting Idiosyncratic Drug Reactions
Elementary Predictive Toxicology for Advanced Applications
The Application of PK/PD Modeling and Simulations During Lead Optimization
Early Preclinical Evaluation of Brain Exposure in Support of Hit Identification and Lead Optimization
Optimizing Biomarker Development for Clinical Studies at the Lead Optimization Stage of Drug Development
The Relevance of Transporters in Determining Drug Disposition.