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Brain Glycogen Metabolism
Title
Brain Glycogen Metabolism [electronic resource] / edited by Mauro DiNuzzo, Arne Schousboe.
ISBN
9783030274801
Edition
1st ed. 2019.
Publication
Cham : Springer International Publishing : Imprint: Springer, 2019.
Physical Description
1 online resource (VIII, 443 p.) 85 illus., 61 illus. in color.
Local Notes
Access is available to the Yale community.
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Access restricted by licensing agreement.
Summary
This book aims to provide a state-of-the-art summary of what is currently known about brain glycogen metabolism, detailing the recent advances in our understanding of why glycogen is so critical for normal brain function. The role of glycogen in cellular neurophysiology remains largely unclear and its specific contribution to the energy demand of brain cells is still elusive.Glycogen is the sole cerebral glucose reserve and is emerging as a fundamental component of brain energy metabolism. Pharmacological or genetic manipulation of glycogen metabolism in the brain impairs memory formation and increases susceptibility to epileptic seizures and cortical spreading depression. Glycogen is also directly implicated in abnormal neuronal excitability and mental retardation that characterize brain disorders like Lafora disease and Pompe disease. .
Variant and related titles
Springer ENIN.
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Printed edition:
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Format
Books / Online
Language
English
Added to Catalog
November 12, 2019
Series
Advances in Neurobiology, 23
Contents
1. Introduction or Preface
2. Structure and regulation of glycogen synthase in the brain
3. Structure and regulation of glycogen phosphorylase in the brain
4. Regional distribution of glycogen in the brain
5. Metabolism of glycogen in the brain white matter
6. Metabolism of glycogen in the brain gray matter
7. Contribution of glycogen to brain energy metabolism
8. Brain glycogen, compartmentation and ion/transmitter homeostasis
9. Role of brain glycogen in learning and memory
10. Brain glycogen content and turnover during sleep-wake cycle
11. Brain glycogen metabolism in response to exercise
12. Brain glycogen metabolism in neuronal excitability and epilepsy
13. Brain glycogen metabolism in hypoglycemia and diabetes. .
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