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Immuno-Oncology Cellular and Translational Approaches
Title
Immuno-Oncology [electronic resource] : Cellular and Translational Approaches / edited by Seng-Lai Tan.
ISBN
9781071601716
Edition
1st ed. 2020.
Publication
New York, NY : Springer US : Imprint: Humana, 2020.
Physical Description
1 online resource (X, 262 p.) 91 illus., 83 illus. in color.
Local Notes
Access is available to the Yale community.
Access and use
Access restricted by licensing agreement.
Summary
This book serves as a guide for identifying and applying commonly used cell-based translational assays as well as for assessing the therapeutic potential of new immuno-oncology therapeutics and advancing their mechanism of action. The detailed chapters within will provide readers with a baseline understanding of the pros and cons as well as key considerations for applying assays that are more reflective of the human immune-tumor microenvironment in order to increase their translatability into the clinic. Written for the Methods in Pharmacology and Toxicology series, the contents of this volume include the kind of specifics and real-world implementation advice to ensure success in the lab. Authoritative and practical, Immuno-Oncology: Cellular and Translational Approaches aims to aid researchers working on biotechnology and pharmaceutical efforts to search for the next generation of safer and more effective cancer immunotherapeutics.
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Springer protocols (Series)
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Format
Books / Online
Language
English
Added to Catalog
February 10, 2020
Series
Methods in Pharmacology and Toxicology,
Contents
An In Vitro System Combining Tumor Cells and Lymphocytes to Predict the In Vivo Response of Immunomodulatory Antibodies
High-Throughput Direct Cell Counting Method for Immuno-Oncology Functional Assays Using Image Cytometry
In Vitro Immunotherapy Potency Assays Using Real-Time Cell Analysis
Assessing the Potency of T Cell-Redirecting Therapeutics Using In Vitro Cancer Cell Killing Assays
Induction and Potential Reversal of a T Cell Exhaustion-Like State: In Vitro Potency Assay for Functional Screening of Immune Checkpoint Drug Candidates
Validation of an Image-Based 3D Natural Killer Cell-Mediated Cytotoxicity Assay
3D-3-Culture: Tumor Models to Study Heterotypic Interactions in the Tumor Microenvironment
Considerations in Developing Reporter Gene Bioassays for Biologics
Miniaturized Single Cell Imaging for Developing Immuno-Oncology Combinational Therapies
Precision Medicine: The Function of Receptor Occupancy in Drug Development
In Vitro Assays for Assessing Potential Adverse Effects of Cancer Immunotherapeutics
The Quest for the Next-Generation of Tumor Targets: Discovery and Prioritization in the Genomics Era.
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