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Autophagy in tumor and tumor microenvironment
Title
Autophagy in tumor and tumor microenvironment [electronic resource] / edited by Sujit Kumar Bhutia.
ISBN
9789811569302
Edition
1st ed. 2020.
Publication
Singapore : Springer Singapore : Imprint: Springer, 2020.
Physical Description
VII, 280 p. 38 illus., 37 illus. in color. online resource.
Local Notes
Access is available to the Yale community.
Access and use
Access restricted by licensing agreement.
Summary
This book deals with the paradoxical role of autophagy in tumor suppression and tumor promotion in cancer cells. Autophagy plays opposing, context-dependent roles in tumors; accordingly, strategies based on inhibiting or stimulating autophagy could offer as potential cancer therapies. The book elucidates the physiological role of autophagy in modulating cancer metastasis, which is the primary cause of cancer-associated mortality. Further, it reviews its role in the differentiation, development, and activation of multiple immune cells, and its potential applications in tumor immunotherapy. In addition, it examines the effect of epigenetic modifications of autophagy-associated genes in regulating tumor growth and therapeutic response and summarizes autophagy's role in the development of resistance to a variety of anti-cancer drugs in cancer cells. In closing, it assesses autophagy as a potential therapeutic target for cancer treatment. Given its scope, the book offers a valuable asset for all oncologists and researchers who wish to understand the potential role of autophagy in tumor biology.
Variant and related titles
Springer ENIN.
Other formats
Printed edition:
Printed edition:
Printed edition:
Format
Books / Online
Language
English
Added to Catalog
November 05, 2020
Contents
Chapter 1. Role of xenobiotic in autophagy inflection in cell death and carcinogenesis
Chapter 2. Autophagy - An agonist and antagonist with an interlink of apoptosis in cancer
Chapter 3. Cross-talk between DNA damage and autophagy and its implication in cancer therapy
Chapter 4. miRNAs and its regulatory role on autophagy in tumor microenvironment
Chapter 5. Exploring the metabolic implications of autophagy modulation in tumor microenvironment
Chapter 6. Mitophagy and Reverse Warburg Effect: Metabolic Compartmentalization of Tumor Microenvironment
Chapter 7. Mitochondrial Biogenesis, Mitophagy, and Mitophagic cell death in Cancer Regulation: A Comprehensive Review
Chapter 8. Mechanical stress-induced autophagy: a key player in cancer metastasis
Chapter 9. The Interplay of Autophagy and the Immune system in the Tumor Microenvironment
Chapter 10. Relevance of autophagy in cancer stem cell and therapeutic
Chapter 11. The Autophagy Conundrum in Cancer Development, Progression and Therapeutics
Chapter 12. Targeting Autophagy in Cancer: Therapeutic implications
Chapter 13. Mechanistic insights into Autophagosome-Lysosome Fusion in Cancer Therapeutics.
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