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Protein Kinase-mediated Decisions Between Life and Death
Title
Protein Kinase-mediated Decisions Between Life and Death [electronic resource] / edited by Ayse Basak Engin, Atilla Engin.
ISBN
9783030498443
Edition
1st ed. 2021.
Publication
Cham : Springer International Publishing : Imprint: Springer, 2021.
Physical Description
1 online resource (VIII, 415 p.) 30 illus., 23 illus. in color.
Local Notes
Access is available to the Yale community.
Access and use
Access restricted by licensing agreement.
Summary
Protein phosphorylation via protein kinases is an inevitable process that alters physiological and pathological functions of the cells. Thus, protein kinases play key roles in the regulation of cell life or death decisions. Protein kinases are frequently a driving factor in a variety of human diseases including aging and cellular senescence, immune system and endothelial dysfunctions, cancers, insulin resistance, cholestasis and neurodegenerative diseases, as well as bacterial resistance in persistent infections. Recent developments in quantitative proteomics provide important opinions on kinase inhibitor selectivity and their modes of action in the biological context. Protein Kinase-mediated Decisions Between Life and Death aims to have the reader catch insights about up-to-date opinions on "Protein Kinases" related pathways that threaten human health and life. As "Protein Kinases" are related to many health problems, clinicians, basic science researchers and students need this information.
Variant and related titles
Springer ENIN.
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Format
Books / Online
Language
English
Added to Catalog
February 05, 2021
Series
Advances in Experimental Medicine and Biology, 1275
Contents
Protein kinase-mediated decision between life and death
Aging, cellular senescence and protein kinases
Oxidative stress-related endothelial cell death and protein kinases
Signal transduction in immune cells and protein kinases
Role of protein kinase C in immune cell activation and its implication chemical-induced immunotoxicity
Metabolic stress and immunity
Activation of tropomyosin-related kinase receptor B by N-acetyl-serotonin: implications for neuroprotection
Protein kinase inhibitors in traumatic brain injury and repair
Amyloid beta toxicity in Alzheimer's Disease and neuronal death-associated protein kinases
Glucolipotoxicity-related beta cell death and protein kinases
Protein kinases and cell death in hematological disorders
A crosstalk between dual-specific phosphatases and dual-specific protein kinases can be a potential therapeutic target for anti-cancer therapy
Bile acid toxicity and protein kinases
Nanoparticle toxicity: Protein kinases and cell death
Two-component signal transduction systems in antibiotic resistance
ERK1/2 MAP kinase, its regulation and role in cellular activities including apoptosis and cell survival. .
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