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Toxicity Assessment Methods and Protocols
Title
Toxicity Assessment [electronic resource] : Methods and Protocols / edited by Carlos Manuel Marques Palmeira, Danielle Palma de Oliveira, Daniel Junqueira Dorta.
ISBN
9781071610916
Edition
1st ed. 2021.
Publication
New York, NY : Springer US : Imprint: Humana, 2021.
Physical Description
1 online resource (XII, 266 p.) 78 illus., 68 illus. in color.
Local Notes
Access is available to the Yale community.
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Access restricted by licensing agreement.
Summary
This book collects protocols from different areas of knowledge to assist in the identification of toxic effects exerted by different xenobiotics. At the same time as classical techniques are presented, modern techniques with alternative models to the use of animals are also presented. Given the ever-increasing exposure to different compounds and their effects on population health, the assessment of multiple endpoints is of utmost importance for better risk assessment, and this collection addresses that need. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Toxicity Assessment: Methods and Protocols aims to serve researchers in this vast field of science as they seek to better understand the mechanisms of action of different xenobiotics.
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Springer protocols (Series)
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Format
Books / Online
Language
English
Added to Catalog
April 12, 2021
Series
Methods in Molecular Biology, 2240
Contents
The Single Cell Gel Electrophoresis Genotoxin Sensitivity Assay
Skin Sensitization Tests: The LLNA and the RhE IL-18 Potency Assay
Skin Equivalent Models: Protocols for In Vitro Reconstruction for Dermal Toxicity Evaluation
Intravital Microscopy: A Tool to Investigate the Toxicity in the Immune System, Vessel Rheology, and Xenobiotic Distribution
Cell-Based Biosensor to Visualize Nitric Oxide Release from Living Cells for Toxicity Assessment
In Vitro Contraction of Isolated Cauda Epididymal Duct Smooth Muscle as a Complimentary Approach to Physiological, Pathological, Toxicological, and Pharmacological Studies on Epididymal Function
Early Life Stage Assays in Zebrafish
Assessment of Urothelial Cytotoxicity at Morphological and Molecular Levels: Urinary Bladder as Target Organ
Evaluation of Development of the Rat Uterus as a Toxicity Biomarker
Acetylcholinesterase (AChE) Activity in Embryos of Zebrafish
Ecotoxicity Assays Using Freshwater Planarians
Toxicogenomic Analysis
Strategy Combining Non-Animal Methods for Ocular Toxicity Evaluation
Immunocytochemistry Analysis of HepG2 Cell 3D Culture Encapsulated as Spheroids in Alginate Beads
Oxygen Consumption Evaluation: An Important Indicator of Metabolic State, Cellular Function and Cell Fate Along Neural Deregulation
Mitochondrial Bioenergetic Assays as a Standard Protocol for Toxicological and Metabolic Assessment
In Vitro Apoptotic Cell Death Assessment.
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