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Metabotropic Glutamate Receptor Technologies
Title
Metabotropic Glutamate Receptor Technologies [electronic resource] / edited by M Foster Olive, Brian T. Burrows, Jonna M. Leyrer-Jackson.
ISBN
9781071611074
Edition
1st ed. 2021.
Publication
New York, NY : Springer US : Imprint: Humana, 2021.
Physical Description
1 online resource (XII, 314 p.) 71 illus., 60 illus. in color.
Local Notes
Access is available to the Yale community.
Access and use
Access restricted by licensing agreement.
Summary
This volume highlights various techniques used to study multiple aspects of mGlu receptor function. Chapters in this book cover topics such as modern approaches for the development and screening of allosteric modulators; fluctuations in intracellular calcium induced by mGlu receptor activation; dopamine-glutamate interactions in the central nervous system; methods for assessing mGlu receptor localization; and common techniques for evaluating mGlu modulation in behavior in rodents, including stress and alcohol drinking. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and practical, Metabotropic Glutamate Receptor Technologies provides researchers with a starting point to address important questions regarding mGlu and its importance. Researchers working in the fields of neuroscience and physiology of multiple peripheral systems will find this volume most useful. .
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Springer protocols (Series)
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Format
Books / Online
Language
English
Added to Catalog
April 12, 2021
Series
Neuromethods, 164
Contents
Technologies for Screening of mGlu Receptor Allosteric Modulators
Positron Emission Tomography (PET) Imaging of Metabotropic Glutamate Receptor Subtype 2 (mGlu2) Based on a Negative Allosteric Modulator Radioligand
PET Imaging of Type 5 Metabotropic Glutamate Receptors
Electrophysiological and Calcium Imaging Approaches to Study Metabotropic Glutamate Receptors
Role of Metabotropic Glutamate Receptors (mGluRs) in the Regulation of Intracellular Calcium Signaling: Theory, Protocols, and Data Analysis
Optical Approaches for Modulating mGlu Receptor Activity
Classic and Modern Approaches to Investigating Interactions between Dopamine Systems and Metabotropic Glutamate Receptors
Using Western Blotting for the Evaluation of Metabotropic Glutamate Receptors within the Nervous System: Procedures and Technical Considerations
Investigation of mGlu Receptor Cell Surface Trafficking in Acute Brain Slices Using Biotinylation
Co-Labeling of Neuronal Cells using DiI Neuronal Filling and Immunohistochemistry to Explore Metabotropic Glutamate Receptor Expression
Fluorescence Immunohistochemistry Techniques for Labelling Metabotropic Glutamate Receptors in the Central Nervous System
Multiplex Arrays for Quantifying Relative Levels of Cytokines in Brain Tissue Lysates: Implications for mGlu Receptor Mediated Alterations
mGlu Receptor Modulation in Murine Models of Stress and Affective Disorders
Role of Metabotropic Glutamate Receptors in Alcohol Drinking Behaviors.
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