9780128212820

0128212829

9780128212813

0128212810

International review of cell and molecular biology ; v. 355

Intro

Actin Cytoskeleton in Cancer Progression and Metastasis

Part A

Copyright

Contents

Contributors

Chapter One: Paxillin family of focal adhesion adaptor proteins and regulation of cancer cell invasion

1. Introduction

2. The paxillin family

3. Fundamentals of cell migration

4. Roles of paxillin and Hic-5 in regulating migration and invasion

4.1. Actin cytoskeleton-mediated effects

4.1.1. Cell plasticity and 3D migration phenotypes

4.1.2. Invadopodia and matrix degradation

4.2. Crosstalk with microtubules

4.3. Crosstalk with intermediate filaments

4.4. Epithelial-mesenchymal transition

5. Stroma-mediated effects on tumor invasion

5.1. Extracellular matrix deposition

5.2. Tumor neovascularization

5.3. Immune cell function

6. Regulation of gene expression

6.1. Regulation of paxillin expression by miRNA

6.2. Regulation of gene expression by Hic-5 and paxillin

7. Paxillin family member mutations and expression in human cancers

8. Therapeutic potential

9. Conclusion

Funding

References

Chapter Two: Nuclear actin in cancer biology

1. Historical perspective

2. There and back again: How actin shuttles to and from the nucleus

3. Now you see it, now you dont: The many faces of nuclear actin

4. Nuclear actin: What itś good for

5. Nuclear actin and cancer: More than meets the eye?

References

Chapter Three: Nuclear actin and myosin in chromatin regulation and maintenance of genome integrity

1. Introduction

2. Evidence that actin, myosin and actin-related proteins are bona fide nuclear proteins

3. Nuclear actin and myosin in transcriptional regulation

4. Chromatin regulation by actin and myosin and the global transcriptional response

5. Nuclear actin in transcriptional reprogramming during differentiation

6. Potential role of nuclear actin and myosin in regulating the 3D genome: a future direction

7. Evidence on the involvement of actin and myosin in genome integrity

8. Actin- and myosin-dependent chromatin remodelers playing a role in genome integrity

9. Actin and myosin as nuclear transporters to maintain genome integrity

10. Actin and myosin in the transcriptional response to DNA damage

11. Concluding remarks

Acknowledgments

References

Chapter Four: The actin-bundling protein L-plastin-A double-edged sword: Beneficial for the immune response, maleficent i ...

1. The actin cytoskeleton and actin-binding proteins

2. Discovery of plastins

3. The plastin family in humans

4. L-plastin structure

5. L-plastin activity regulation by Ca

6. L-plastin functions: Impact of post-translational modification

6.1. L-plastin primordial function: F-actin-binding and -bundling

6.2. Associated functions of L-plastin

6.2.1. During embryonic development

6.2.2. Endocytosis