9780128212844

0128212845

9780128212837

0128212837

ebook version :

Original

International review of cell and molecular biology ; v. 356

Intro

Actin Cytoskeleton in Cancer Progression and Metastasis

Part B

Copyright

Contents

Contributors

Chapter One: Two sides of the coin: Cytoskeletal regulation of immune synapses in cancer and primary immune deficiencies

1. Immune cells on the move-Requirement for actin cytoskeleton dynamics

1.1. Seeding de novo actin filaments

1.2. Nucleation promoting factors

1.3. Regulation of actin filaments by Rho GTPases

1.4. Actin polymerization in immune cells

2. Actin in cell-cell contacts: Immunological synapses

2.1. Cytolytic control of malignant transformation

2.1.1. The cytolytic immunological synapse

2.1.2. Receptor triggering

2.1.2.1. T cells

2.1.2.2. Natural Killer cells

2.1.3. Lytic granule convergence

2.1.4. Repositioing the microtubule-organizing centre

2.1.5. Lytic granule exocytosis

2.2. B cells: Gathering and endocytosis of antigen

2.3. Dendritic cell synapses and cross-presentation

2.4. Integrins at immunological synapses

3. Primary immunodeficiency diseases reveal the critical role of actin regulators in immune cells

3.1. Signal transduction via Rho GTPas: Regulatory mechanisms

3.1.1. Rho guanine-nucleotide exchange factor 1 (ARHGEF1)

3.1.2. Ras homolog family member A (RhoA)

3.1.3. Ras-related C3 botulinum toxin substrate (Rac)

3.1.3.1. Rac2

3.1.3.2. Rac1

3.1.4. Cell division control protein 42 homologue (CDC42)

3.1.5. Atypical Rho GTPases

3.1.5.1. Ras homologue family member H (RhoH)

3.1.5.2. Ras homology growth-related (RhoG)

3.1.6. Dedicator of cytokinesis (DOCK) family of proteins

3.1.6.1. DOCK2

3.1.6.2. DOCK8

3.1.6.3. RAS Guanyl releasing protein 1 (RASGRP1)

3.8. Actin nucleation: Actin-related protein 2/3 complex subunit 1B (ARPC1B)

4. Actin in cell transformation

4.1. Cell transformation: The role of actin in the nucleus

4.2. Cellular rigidity or stiffness: Targeting the cell cytoskeleton

5. Clinical relevance and therapy

Acknowledgments

References

Chapter Two: Actin remodeling and vesicular trafficking at the tumor cell side of the immunological synapse direct evasio ...

1. Introduction

2. Actin cytoskeleton remodeling in mounting tumor resistance to cytotoxic lymphocytes