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Antiepileptic Drug Discovery Novel Approaches
Title
Antiepileptic Drug Discovery [electronic resource] : Novel Approaches / edited by Alan Talevi, Luisa Rocha.
ISBN
9781493963553
Edition
1st ed. 2016.
Publication
New York, NY : Springer New York : Imprint: Humana, 2016.
Physical Description
1 online resource (XI, 386 p.) 51 illus., 42 illus. in color.
Local Notes
Access is available to the Yale community.
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Access restricted by licensing agreement.
Summary
This thorough volume delves into antiepileptic drug discovery with a comprehensive collection of innovative approaches for the development of antiepileptic therapies, focusing on novel molecular targets for antiepileptic drugs, computer-aided approaches for the identification of new drug candidates, and therapeutic strategies to overcome refractory epilepsy. The last section illustrates the potential benefits that network pharmacology and rational drug repurposing could bring to the antiepileptic drug discovery community. Written for the Methods in Pharmacology and Toxicology series, chapters include the kind of detailed description and implementation advice to ensure results in the laboratory. Authoritative and practical, Antiepileptic Drug Discovery: Novel Approaches aims to provide medicinal chemists, pharmacologists, and other researchers with the tools need to further explore the study of pharmacoresistant epilepsy and the discovery of new antiepileptic drugs.
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Format
Books / Online
Language
English
Added to Catalog
November 03, 2021
Series
Methods in Pharmacology and Toxicology,
Contents
Inflammatory Cytokines as Targets for Epilepsy Drug Therapy
The Use of Anti-Inflammatory Drugs in Epilepsy
Carbonic Anhydrase and Epilepsy
Synaptic Vesicle Protein 2A as a Novel Pharmacological Target with Broad Potential for New Antiepileptic Drugs
Do Cannabinoids Represent a Good Therapeutic Strategy for Epilepsy?
Glutamate Receptors as Targets for Novel Antiepileptic Drug Therapy
Neurosteroid Regulation of Seizures: Role of GABAA Receptor Plasticity
Erythropoietin as Potential Neuroprotective and Antiepileptogenic Agent in Epilepsy and Refractory Epilepsy
Caloric Restriction and Dietary Treatments of Epilepsy: Mechanistic Insights for Drug Discovery
Gene Therapy in Epilepsy
Human Brain Tissue as a Model for the Study of Epilepsy
The Blood-Brain Barrier and the Design of New Antiepileptic Drugs
Virtual Screening Applications in the Search of Novel Antiepileptic Drug Candidates
Discovering New Antiepileptic Drugs Addressing the Transporter Hypothesis of Refractory Epilepsy: Ligand-Based Approximations
Discovering New Antiepileptic Drugs Addressing the Transporter Hypothesis of Refractory Epilepsy: Structure-Based Approximations
Nanoformulations of Antiepileptic Drugs: In Vitro and In Vivo Studies
Side Effects of Antiepileptic Drugs
Network Pharmacology and Epilepsy
The Importance of Drug Repurposing in the Field of Antiepileptic Drug Development.
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