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Cannabinoids
Title
Cannabinoids [electronic resource] / edited by Roger G. Pertwee.
ISBN
9783540265733
Publication
Berlin, Heidelberg : Springer Berlin Heidelberg, 2005.
Physical Description
1 online resource (XII, 772 p.) 87 illus., 3 illus. in color.
Local Notes
Access is available to the Yale community.
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Access restricted by licensing agreement.
Summary
Less than 20 years ago the ?eld of cannabis and the cannabinoids was still c- sidered a minor, somewhat quaint, area of research. A few groups were active in the ?eld, but it was already being viewed as stagnating. The chemistry of cannabis 9 9 was well known, ? -tetrahydrocannabinol (? -THC), identi?ed in 1964, being the only major psychoactive constituent and cannabidiol, which is not psychoactive, possibly contributing to some of the effects. These cannabinoids and several s- thetic analogs had been thoroughly investigated for their pharmacological effects. Their mode of action was considered to be non-speci?c. The reasons for this - sumption were both technical and conceptual. On the technical side, it had been shown that THC was active in both enantiomeric forms (though with a different level of potency) and this observation was incompatible with action on biological substrates-a receptor, an enzyme, an ion channel-which react with a single stereoisomer only. The conceptual problem related to THC activity. This had been pointed out by several highly regarded research groups that had shown that many of the effects seen with cannabinoids were related to those of biologically active lipophiles, and that many of the effects of THC, particularly chronic ones, were comparable to those seen with anaesthetics and solvents.
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Format
Books / Online
Language
English
Added to Catalog
May 19, 2022
Series
Handbook of Experimental Pharmacology, 168
Contents
Pharmacological Actions of Cannabinoids
Cannabinoid Receptor Signaling
Molecular Biology of Cannabinoid Receptors
Analysis of the Endocannabinoid System by Using CB1 Cannabinoid Receptor Knockout Mice
The Biosynthesis, Fate and Pharmacological Properties of Endocannabinoids
Modulators of Endocannabinoid Enzymic Hydrolysis and Membrane Transport
Structural Requirements for Cannabinoid Receptor Probes
Cannabinoid Receptors and Their Ligands: Ligand-Ligand and Ligand-Receptor Modeling Approaches
The Phylogenetic Distribution and Evolutionary Origins of Endocannabinoid Signalling
Distribution of Cannabinoid Receptors in the Central and Peripheral Nervous System
Effects of Cannabinoids on Neurotransmission
Retrograde Signalling by Endocannabinoids
Effects on the Immune System
Imaging of the Brain Cannabinoid System
Cannabinoid Function in Learning, Memory and Plasticity
Cannabinoid Control of Motor Function at the Basal Ganglia
Cannabinoid Mechanisms of Pain Suppression
Effects of Cannabinoids on Hypothalamic and Reproductive Function
Cannabinoids and the Digestive Tract
Cardiovascular Pharmacology of Cannabinoids
Effects on Cell Viability
Effects on Development
Pharmacokinetics and Metabolism of the Plant Cannabinoids, ?9-Tetrahydrocannibinol, Cannabidiol and Cannabinol
Cannabinoid Tolerance and Dependence
Human Studies of Cannabinoids and Medicinal Cannabis.
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