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Vertebrate Motoneurons
Title
Vertebrate Motoneurons [electronic resource] / edited by Michael J. O'Donovan, Mélanie Falgairolle.
ISBN
9783031071676
Edition
1st ed. 2022.
Publication
Cham : Springer International Publishing : Imprint: Springer, 2022.
Physical Description
1 online resource (XII, 400 p.) 81 illus., 64 illus. in color.
Local Notes
Access is available to the Yale community.
Access and use
Access restricted by licensing agreement.
Summary
This book aims to provide a comprehensive and timely review of new findings in motoneuron research. Recent findings have revealed that motoneurons are more complex and have more extensive functions than previously imagined. Some of the molecular and genetic pathways that orchestrate the development of motoneurons have been discovered, as have the mechanisms responsible for the selective innervation of muscles by specific pools of motoneurons. These novel findings are revolutionizing ideas about the function of motoneurons and have important implications for motoneuron disease. Chapters from several of the foremost figures in the field are included in this book and will emphasize how basic science is the engine driving the discovery of novel treatments for degenerative motoneuron diseases. Cutting edge developments in the use of pluripotent stem cells to correct motoneuron disease will be also be covered. This book would be useful to students of basic motoneuron physiology, locomotor behavior and motor control. This book would also be of interest to professional neuroscientists, neurologists, and neurosurgeons.
Variant and related titles
Springer ENIN.
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Format
Books / Online
Language
English
Added to Catalog
September 08, 2022
Series
Advances in Neurobiology, 28
Contents
Establishing the molecular and functional diversity of spinal motoneurons
Chloride homeostasis in developing motoneurons
Normal development and pathology of motoneurons: anatomy, electrophysiological properties, firing patterns and circuit connectivity
Homeostatic regulation of motoneuron properties in development
Homeostatic plasticity of the mammalian neuromuscular junction
Diversity of mammalian motoneurons and motor units
Synaptic projections of motoneurons within the spinal cord
Recruitment of motoneurons
Electrical properties of adult mammalian motoneurons.-The cellular basis for the generation of firing patterns in human motor units
Motoneuronal regulation of central pattern generator and network function
Extraocular motoneurons and neurotrophism
Motoneuron diseases
Electrical and morphological properties of developing motoneurons in postnatal mice and early abnormalities in sod1 transgenic mice
From physiological properties to selective vulnerability of motor units in amyotrophic lateral sclerosis. .
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