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The Quintessence of Basic and Clinical Research and Scientific Publishing
Title
The Quintessence of Basic and Clinical Research and Scientific Publishing [electronic resource] / edited by Gowraganahalli Jagadeesh, Pitchai Balakumar, Fortunato Senatore.
ISBN
9789819912841
Edition
1st ed. 2023.
Publication
Singapore : Springer Nature Singapore : Imprint: Springer, 2023.
Physical Description
XXII, 941 p. 1 illus.
Local Notes
Access is available to the Yale community.
Access and use
Access restricted by licensing agreement.
Summary
The book, intended for biomedical researchers, attempts to foster a comprehensive understanding of the elements that impact scientific research, such as clinical trial design, communication, and publication methods. It introduces the process of idea generation and creative/critical thinking, leading to the development of key concepts that coalesce into theoretical constructs and working hypotheses. The book systematically delineates research phases associated with a bench-to-bedside translational approach, providing the full depth and breadth of drug discovery and development: design, synthesis, and optimization of drug candidates interacting with targets linked to diseases, as well as clinical trial design to acquire substantial evidence of efficacy and safety for candidate drugs in the target patient population. New and evolving topics such as artificial intelligence, machine and deep learning, drug repurposing approaches, and bioinformatics, are incorporated into the text as these features are becoming integrated into drug research and development. Additionally, it covers publication strategies, including literature search, manuscript preparation, data presentation, relevant discussion, editorial processes, elements of peer review, and bibliometrics. Finally, the book addresses grantsmanship, key strategies for building effective networks, mentorships, maintaining research integrity, and forging career advancement opportunities, including entrepreneurship.
Variant and related titles
Springer ENIN.
Other formats
Printed edition:
Printed edition:
Printed edition:
Format
Books / Online
Language
English
Added to Catalog
October 03, 2023
Contents
Chapter 1. The Roadmap to Research: Fundamentals of a Multifaceted Research Process
Chapter 2. Processes involved in the generation of novel ideas
Chapter 3. Creativity and critical thinking contribute to scholarly achievement
Chapter 4. Writing protocols in Pharmacological studies
Chapter 5. Basics of Designing General Toxicology Studies
Chapter 6. General design considerations in Reproductive and developmental toxicity studies
Chapter 7. Genetic toxicology studies
Chapter 8. Rodent Carcinogenicity Studies.-Chapter 9. Designing studies in pharmaceutical and medicinal chemistry
Chapter 10. Experimental protocols in phytochemistry and natural products: an ever-evolving challenge
Chapter 11. Drug substance/ product quality analysis (Quality assessment)
Chapter 12. Drug Delivery Systems: Lipid Nanoparticles Technology in Clinic
Chapter 13. Pharmacokinetic studies for drug development
Chapter 14. New Alternative Methods in drug safety assessment
Chapter 15. Animal models for the study of human disease
Chapter 16. Physiologically based Pharmacokinetic Modelling in Drug Discovery and Clinical Development: A Treatise on Concepts, Model Workflow, Credibility, Application and Regulatory Landscape
Chapter 17. Design and conduct of pharmacokinetics studies influenced by extrinsic factors
Chapter 18. Specific Populations: Clinical Pharmacology Considerations
Chapter 19. Impact of genetic variation on drug response.-Chapter 20. Phases of clinical trials
Chapter 21. Common clinical trial designs
Chapter 22. Elements of clinical trial protocol design
Chapter 23. Good clinical practice in clinical trials, substantial evidence of efficacy, and interpretation of the evidence
chapter 24. Grandfathered Drugs of 1938 in the United States
Chapter 25. General overview of the statistical issues in clinical study designs
Chapter 26. Introduction to pharmacoepidemiology and its application in clinical research
Chapter 27. Pharmacovigilance through phased clinical trials, post-marketing surveillance and ongoing life cycle safety
Chapter 28. The design and statistical analysis of randomized pre-clinical experiments
Chapter 29. Descriptive and Inferential Statistics in Biomedical Sciences: an overview
Chapter 30. Principles and applications of statistics in biomedical research: parametric and non-parametric tests including tests employed for Post-hoc analysis
Chapter 31. Artificial intelligence generative chemistry design of target-specific scaffold-focused small molecule drug libraries
Chapter 32. Artificial intelligence technologies for clinical data pharmacoanalytics. Case studies on Alzheimer's disease
Chapter 33. Bioinformatics: Theory and Application
Chapter 34. Drug targets and drug discovery research
Chapter 35. Role of Nonclinical Programs in Drug Development
Chapter 36. Drug repurposing: strategies and study design in bringing back old drugs to the mainline
Chapter 37. Empowering knowledge on efficient literature search: an overview of biomedical search engines and databases
Chapter 38. Literature Reviews: An Overview of Systematic, Integrated, and Scoping Review
Chapter 39. How To Create A Bibliography
Chapter 40. Publication metrics /Bibliometrics
Chapter 41. How to write a scientific paper
Chapter 42. Preparing and structuring a manuscript for publication
Chapter 43. Writing a scientific article
Chapter 44. How to Present Results in a Research Paper
Chapter 45. Communicating results of quantitative research
Chapter 46. How to Efficiently Write a Persuasive Discussion Section
Chapter 47. Submitting a manuscript for publication, the peer review process, and getting past the gatekeepers
Chapter 48. Writing a Postgraduate or Doctoral Thesis: A Step-by-Step Approach
Chapter 49. Poster presentation at scientific meetings
Chapter 50. Strategies for the preparation and delivery of oral presentation
Chapter.-51. Grant Process and Peer Review ─ US National Institutes of Health System
Chapter 52. Rigor and specifics in writing research proposal
Chapter 53. Writing research grant proposals ─ from an Indian Perspective
Chapter 54. Funding opportunities (resources) in biomedical sciences: Indian perspective
Chapter 55. Mentorship in biomedical sciences
chapter 56. Commercializing the technology - transitioning from the academic lab to the market
Chapter 57. Patent law fundamentals for biomedical scientists
Chapter 58. Research integrity: responsible conduct of research
Chapter 59. Publication integrity, authorship, and misconduct.
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