"Developed from a symposium sponsored by the Division of Agricultural and Food Chemistry at the 204th National Meeting of the American Chemical Society, Washington, D.C., August 23-28, 1992."

Distributed in print by Oxford University Press.

Description based on publisher-supplied information and home-page.

Original

Online version

Original

ACS symposium series, 553

Nitrosamine and N-Nitroso Compound Chemistry and Biochemistry: Advances and Perspectives / Loeppky, Richard N. / http://dx.doi.org/10.1021/bk-1994-0553.ch001

Nitrosamines in Sunscreens and Cosmetic Products: Occurrence, Formation, and Trends / Havery, Donald C.; Chou, Hardy J. / http://dx.doi.org/10.1021/bk-1994-0553.ch002

N-Nitrosodimethylamine in Nonfat Dry Milk / Scanlan, R. A.; Barbour, J. F.; Bodyfelt, F. W.; Libbey, L. M. / http://dx.doi.org/10.1021/bk-1994-0553.ch003

Prevention of Nitrosamine Exposure in the Rubber Industry / Spiegelhalder, B.; Wacker, C.-D. / http://dx.doi.org/10.1021/bk-1994-0553.ch004

Blocking Nitrosamine Formation: Understanding the Chemistry of Rapid Nitrosation / Loeppky, Richard N.; Bao, Yen T.; Bae, Jaeyoung; Yu, Li; Shevlin, Graziella / http://dx.doi.org/10.1021/bk-1994-0553.ch005

Quantitative Aspects of Nitrosamine Denitrosation / Williams, D. L. H. / http://dx.doi.org/10.1021/bk-1994-0553.ch006

Peptide Nitrosations / Challis, Brian C., Chemistry Department, Open University, Milton Keynes, MK7 6AA, United Kingdom, Chemistry Department, Imperial College, London SW7 2AZ, United Kingdom; Carman, Neil, Chemistry Department, Open University, Milton Keynes, MK7 6AA, United Kingdom; Fernandes, Maria H. R., Chemistry Department, Imperial College, London SW7 2AZ, United Kingdom; Glover, Benjamin R., Chemistry Department, Imperial College, London SW7 2AZ, United Kingdom; Latif, Farida, Chemistry Department, Imperial College, London SW7 2AZ, United Kingdom; Patel, Pravin, Chemistry Department, Open University, Milton Keynes, MK7 6AA, United Kingdom; Sandhu, Jaswinder S., Chemistry Department, Open University, Milton Keynes, MK7 6AA, United Kingdom, Chemistry Department, Imperial College, London SW7 2AZ, United Kingdom; Shuja, Shabaz, Chemistry Department, Open University, Milton Keynes, MK7 6AA, United Kingdom / http://dx.doi.org/10.1021/bk-1994-0553.ch007

Nitrosatable Secondary Amines: Exogenous and Endogenous Exposure and Nitrosation In Vivo / Tricker, A. R., Current address: Wissenschaftliche Abteilung, Verband der Cigarettenindustrie, Königswintererstrasse 550, 53227 Bonn, Germany; Pfundstein, B.; Preussmann, R. / http://dx.doi.org/10.1021/bk-1994-0553.ch008

Improved Methods for Analysis of N-Nitroso Compounds and Applications in Human Biomonitoring / Pignatelli, B.; Malaveille, C.; Thuillier, P.; Hautefeuille, A.; Bartsch, H. / http://dx.doi.org/10.1021/bk-1994-0553.ch009

DNA Damage and Cytotoxicity Caused by Nitric Oxide / Tannenbaum, Steven R., Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, Division of Toxicology, Massachusetts Institute of Technology, Cambridge, MA 02139; Tamir, Snait, Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139; de Rojas-Walker, Teresa, Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139; Wishnok, John S., Division of Toxicology, Massachusetts Institute of Technology, Cambridge, MA 02139 / http://dx.doi.org/10.1021/bk-1994-0553.ch010

Chemistry of the "NONOates": Unusual N-Nitroso Compounds Formed by Reacting Nitric Oxide with Nucleophiles / Keefer, Larry K., Chemistry Section, Laboratory of Comparative Carcinogenesis, Frederick Cancer Research and Development Center, National Cancer Institute, Frederick, MD 21702; Christodoulou, Danae, Chemistry Section, Laboratory of Comparative Carcinogenesis, Frederick Cancer Research and Development Center, National Cancer Institute, Frederick, MD 21702; Dunams, Tambra M., Chemistry Section, Laboratory of Comparative Carcinogenesis, Frederick Cancer Research and Development Center, National Cancer Institute, Frederick, MD 21702; Hrabie, Joseph A., CSAL, PRI/DynCorp, Frederick Cancer Research and Development Center, National Cancer Institute, Frederick, MD 21702; Maragos, Chris M., Chemistry Section, Laboratory of Comparative Carcinogenesis, Frederick Cancer Research an Development Center, National Cancer Institute, Frederick, MD 21702; Saavedra, Joseph E., Chemistry Section, Laboratory of Comparative Carcinogenesis, Frederick Cancer Research and Development Center, National Cancer Institute, Frederick, MD 21702; Wink, David A., Chemistry Section, Laboratory of Comparative Carcinogenesis, Frederick Cancer Research and Development Center, National Cancer Institute, Frederick, MD 21702 / http://dx.doi.org/10.1021/bk-1994-0553.ch011

Nitric Oxide Production and Catalysis of N-Nitroso Compound Formation by Woodchucks (Marmota monax) and Woodchuck Hepatocytes in Culture / Hotchkiss, J. H.; Liu, R. H.; Lillard, T. J. / http://dx.doi.org/10.1021/bk-1994-0553.ch012

Activation of N-Nitrosodialkylamines by Metalloporphyrin Models of Cytochrome P-450 / Mochizuki, M.; Okochi, E.; Shimoda, K.; Ito, K. / http://dx.doi.org/10.1021/bk-1994-0553.ch013

Kinetics and Enzymes Involved in the Metabolism of Nitrosamines / Yang, Chung S.; Smith, Theresa J.; Hong, Jun-Yan; Zhou, Shiqi / http://dx.doi.org/10.1021/bk-1994-0553.ch014

Potential Mechanism of Action of Nitrosamines with Hydroxy, Oxo, or Carboxy Groups / Eisenbrand, G.; Janzowski, C. / http://dx.doi.org/10.1021/bk-1994-0553.ch015

Activation of β-Hydroxyalkylnitrosamines: Evidence for Involvement of a Sulfotransferase / Michejda, Christopher J.; Koepke, Steven R.; Kroeger Koepke, Marilyn B.; Hernandez, Lidia / http://dx.doi.org/10.1021/bk-1994-0553.ch016

Hemoglobin Adducts, DNA Adducts, and Urinary Metabolites of Tobacco-Specific Nitrosamines: As Biochemical Markers of Their Uptake and Metabolic Activation in Humans / Hecht, Stephen S.; Trushin, Neil; Carmella, Steven G. / http://dx.doi.org/10.1021/bk-1994-0553.ch017

Metabolism of N'-Nitrosonornicotine by Rat Liver, Oral Tissue, and Esophageal Microsomes / Murphy, Sharon E.; Spina, Deborah A.; Heiblum, Rachel / http://dx.doi.org/10.1021/bk-1994-0553.ch018

Mechanisms of Inhibition of Tobacco-Specific Nitrosamine-Induced Lung Tumorigenesis in A/J Mice / Chung, Fung-Lung; Morse, Mark M., Current address: Arthur James Cancer Hospital and Research Institute, Ohio State University, Columbus, OH 43210; Eklind, Karin I., Current address: Astra AB, 15185 Södertälje, Sweden; Xu, Yong, Current address: Institute of Nutrition and Food Hygiene, Chinese Academy of Preventive Medicine, 29 Nan-Wei Road, Beijing 10050, China / http://dx.doi.org/10.1021/bk-1994-0553.ch019

Chemical Structure of Nitrosamines Related to Carcinogenesis / Lijinsky, William / http://dx.doi.org/10.1021/bk-1994-0553.ch020

Formation of Tobacco-Specific Nitrosamines: Carcinogenicity and Role of Dietary Fat in Their Carcinogenicity / Hoffmann, Dietrich; Rivenson, Abraham; Wynder, Ernst L.; Hecht, Stephen S. / http://dx.doi.org/10.1021/bk-1994-0553.ch021

Possible Mechanisms of N-Nitrosodimethylamine Hepatotoxicity / Archer, Michael C.; Chin, Wei; Lee, Valentia M. / http://dx.doi.org/10.1021/bk-1994-0553.ch022

Genetic Tumor Epidemiology: Identifying Causative Carcinogenic Agents and Their Transforming Mutations / Ludeke, B. I.; Ohgaki, H.; Kleihues, P. / http://dx.doi.org/10.1021/bk-1994-0553.ch023

Electrophilic Addition to "AminoNONOate" (R1R2NN(O)NO-) Ions / Saavedra, Joseph E., Laboratory of Comparative Carcinogenesis, Frederick Cancer Research and Development Center, National Cancer Institute, Frederick, MD 21702; Dunams, Tambra M., Laboratory of Comparative Carcinogenesis, Frederick Cancer Research and Development Center, National Cancer Institute, Frederick, MD 21702; Flippen-Anderson, Judith L., Naval Research Laboratory, Washington, DC 20375; Keefer, Larry K., Laboratory of Comparative Carcinogenesis, Frederick Cancer Research and Development Center, National Cancer Institute, Frederick, MD 21702 / http://dx.doi.org/10.1021/bk-1994-0553.ch024

Nitric Oxide-Nucleophile Complexes as Ligands: Structural Aspects of the Coordinated "NONOate" Functional Group in Novel Mixed-Ligand, Non-Nitrosyl Metal Complexes / Christodoulou, Danae, Chemistry Section, Laboratory of Comparative Carcinogenesis, Frederick Cancer Research and Development Center, National Cancer Institute, Frederick, MD 21702; Wink, David A., Chemistry Section, Laboratory of Comparative Carcinogenesis, Frederick Cancer Research and Development Center, National Cancer Institute, Frederick, MD 21702; George, Clifford F., Laboratory for the Structure of Matter, Naval Research Laboratory, Washington, DC 20375; Saavedra, Joseph E., Chemistry Section, Laboratory of Comparative Carcinogenesis, Frederick Cancer Research and Development Center, National Cancer Institute, Frederick, MD 21702; Keefer, Larry K., Chemistry Section, Laboratory of Comparative Carcinogenesis, Frederick Cancer Research and Development Center, National Cancer Institute, Frederick, MD 21702 / http://dx.doi.org/10.1021/bk-1994-0553.ch025

Radical Cations in Nitrosation of tert-Dialkyl Aromatic Amines / Singh, S.; Hastings, R.; Loeppky, Richard N. / http://dx.doi.org/10.1021/bk-1994-0553.ch026

Nitrosamide Formation from Foodstuffs / Mende, P.; Preussmann, R.; Spiegelhalder, B. / http://dx.doi.org/10.1021/bk-1994-0553.ch027

Tocopherol Inhibition of NO2-Mediated Nitrosation: In Vitro and Biological Superiority of γ-Tocopherol / Cooney, R. V.; Franke, A. A.; Mordan, L. J.; Harwood, P. J.; Hatch-Pigott, V.; Custer, L. J. / http://dx.doi.org/10.1021/bk-1994-0553.ch028

pH Changes in Smokeless Tobaccos Undergoing Nitrosation / Andersen, R. A., Agricultural Research Service, U.S. Department of Agriculture, Department of Agronomy, University of Kentucky, Lexington, KY 40546-0091, Department of Agronomy, University of Kentucky, Lexington, KY 40546; Fleming, P. D., Agricultural Research Service, U.S. Department of Agriculture, Department of Agronomy, University of Kentucky, Lexington, KY 40546-0091, Department of Agronomy, University of Kentucky, Lexington, KY 40546; Hamilton-Kemp, T. R., Department of Horticulture, University of Kentucky, Lexington, KY 40546; Hildebrand, D. F., Department of Agronomy, University of Kentucky, Lexington, KY 40546 / http://dx.doi.org/10.1021/bk-1994-0553.ch029

Oxidation of Alkylnitrosamines via the Fenton Reagent: Use of Nitrosamines To Probe Oxidative Intermediates in the Fenton Reaction / Wink, David A., Frederick Cancer Research and Development Center, National Cancer Institute, Frederick, MD 21702; Nims, Raymond W., Frederick Cancer Research and Development Center, National Cancer Institute, Frederick, MD 21702; Saavedra, Joseph E., Frederick Cancer Research and Development Center, National Cancer Institute, Frederick, MD 21702; Desrosiers, Marc F., National Institute of Standards and Technology, Gaithersburg, MD 20899; Ford, Peter C., University of California, Santa Barbara, CA 98106 / http://dx.doi.org/10.1021/bk-1994-0553.ch030

Structures of Mutagens Formed from Fenton-Type Oxidation of N-Nitrosodialkylamines / Mochizuki, M.; Tsutsumi, N.; Hizatate, S.; Okochi, E. / http://dx.doi.org/10.1021/bk-1994-0553.ch031

Metabolism of Methylbutyl- and Methylamylnitrosamine by Rat and Human Esophagus and Other Tissues and Induction of Esophageal Adenocarcinoma in Rats / Mirvish, S. S., Eppley Institute for the Research of Cancer, University of Nebraska Medical Center, Omaha, NE 68198; Huang, Q., Eppley Institute for the Research of Cancer, University of Nebraska Medical Center, Omaha, NE 68198; Chen, S. C., Eppley Institute for the Research of Cancer, University of Nebraska Medical Center, Omaha, NE 68198; Park, S. S., National Cancer Institute, Bethesda, MD 20892; Gelboin, H. V., National Cancer Institute, Bethesda, MD 20892 / http://dx.doi.org/10.1021/bk-1994-0553.ch032

Chemistry of Putative Intermediates in Bioactivation of β-Oxidized Nitrosamines / Loeppky, Richard N.; Erb, Eric; Srinivasan, Aloka; Yu, Li / http://dx.doi.org/10.1021/bk-1994-0553.ch033

Modulation of N-Nitrosomethylbenzylamine Metabolism in Rats by Concurrently Administered Ethanol and Diallyl Sulfide / Ludeke, B. I.; Yamada, Y.; Dominé, F.; Kleihues, P. / http://dx.doi.org/10.1021/bk-1994-0553.ch034

DNA Adducts Induced by Pancreas-Specific Nitrosamines / Kokkinakis, Demetrius M., Southwestern Medical Center, University of Texas, 5323 Harry Hines Boulevard, Dallas, TX 75235-9036; Norgle, Jeffrey R., Northwestern University, 710 Fairbanks Court, Chicago, IL 60611 / http://dx.doi.org/10.1021/bk-1994-0553.ch035

DNA Pyridyloxobutylation: 4-(Acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone Inhibits the Repair of O 6-Methylguanine / Peterson, Lisa A.; Liu, Xiao-Keng; Hecht, Stephen S. / http://dx.doi.org/10.1021/bk-1994-0553.ch036

Sequence-Specific Methylation of Single- and Double-Stranded DNA by Methylnitrosourea / Wurdeman, R. W.; Gold, B. / http://dx.doi.org/10.1021/bk-1994-0553.ch037

Detection of Tobacco-Related Hemoglobin Adducts by Quadrupole Mass Spectrometry / Richter, E.; Falter, B.; Kutzer, C.; Schulze, J. / http://dx.doi.org/10.1021/bk-1994-0553.ch038

Nonvolatile N-Nitrosamides in Dried Squid: Analysis by High-Performance Liquid Chromatography-Photolysis-Chemiluminescence / Kim, S. H., Cheju National University, Cheju-do, Korea; Hotchkiss, J. H., Institute of Food Science, Stocking Hall, Cornell University, Ithaca, NY 14853 / http://dx.doi.org/10.1021/bk-1994-0553.ch039

N-Nitrosodiphenylamine in Diphenylamine-Treated Apples: Analysis by High-Performance Liquid Chromatography-UV Photolysis-Chemiluminescence / Lillard, T. J.; Hotchkiss, J. H. / http://dx.doi.org/10.1021/bk-1994-0553.ch040

Accumulation of Tobacco-Specific Nitrosamines during Curing and Aging of Tobacco / Burton, H. R.; Bush, L. P. / http://dx.doi.org/10.1021/bk-1994-0553.ch041

Human Exposure to a Tobacco-Specific Nitrosamino Acid / Tricker, A. R., Analytisch-biologisches Forschungslabor Professor Doktor F. Adlkofer, Goethestrasse 20, D-800 Munich, Germany, Current address: Wissenschaftliche Abteilung, Verband der Cigarettenindustrie, Königswintererstrasse 550, 53227 Bonn, Germany; Scherer, G., Analytisch-biologisches Forschungslabor Professor Doktor F. Adlkofer, Goethestrasse 20, D-800 Munich, Germany; Adlkofer, F., Analytisch-biologisches Forschungslabor Professor Doktor F. Adlkofer, Goethestrasse 20, D-800 Munich, Germany; Pachinger, A., Ökolab, Gesellschaft für Umweltanalytik, Hasnerstrasse 124a, A-1160 Vienna, Austria; Klus, H., Ökolab, Gesellschaft für Umweltanalytik, Hasnerstrasse 124a, A-1160 Vienna, Austria / http://dx.doi.org/10.1021/bk-1994-0553.ch042

Significance of Nitrosamines in Betel Quid Carcinogenesis / Prokopczyk, Bogdan; Krzeminski, Jacek; Hoffmann, Dietrich / http://dx.doi.org/10.1021/bk-1994-0553.ch043

Characterization of N-Nitrosamino Acids in Tobacco Products and Assessment of Their Carcinogenic Potential / Djordjevic, Mirjana V.; Fan, Jingrun; Krzeminski, Jacek; Brunnemann, Klaus D.; Hoffmann, Dietrich / http://dx.doi.org/10.1021/bk-1994-0553.ch044

Analysis of Tobacco-Specific Nitrosamines in Tobacco and Tobacco Smoke / Brunnemann, Klaus D.; Hoffmann, Dietrich / http://dx.doi.org/10.1021/bk-1994-0553.ch045

Nitroso compounds > Analysis.

Rubber industry workers > Health risk assessment.

Nitrosoamines > Carcinogenicity.

Nitrosoamines > Formation > Control.

Nitrosoamines > Effect of acid on.

Nitroso compounds > Analysis > Methodology.

Nitric oxide > Toxicity.

Nitric oxide > Experiments > Analysis.

Nitrosoamines > Metabolism > Analysis.

Nitroso compounds > Metabolism.

Nitrosoamines > Carcinogenicity > Structure.

Lungs > Cancer > Research.

Nitrosoamines > Carcinogenicity > Analysis.

Tobacco > Analysis.

Tobacco > Composition.

Fat > Toxicology.

Hepatotoxicology > Research.

Carcinogens > Detection.

Nitric oxide > Experiments.

Nitroso compounds > Structure > Research.

Nitrosamides > Formation.

Vitamin E > Variation > Utilization.

Nitrosation > Experiments.

Fenton's reagent > Utilization.

Mutagens > Structure.

Adenocarcinoma > Research.

Nitrosoamines > Oxidation.

DNA adducts > Experiments.

Nitroso compounds > Metabolism > Control.

DNA > Methylation.

Diphenylamine > Detection.

Tobacco curing > Analysis.

Nitrosoamines > Physiological effect.

Tobacco products > Carcinogenicity > Evaluation.

Tobacco smoke > Analysis.

Nitrosamines.

Nitroso Compounds.

Sunscreening Agents - chemistry.

Cosmetics - chemistry.

Dimethylnitrosamine - analysis.

Milk - chemistry.

Rubber - chemistry.

Peptides.

Nitrosation.

Amines - analysis.

DNA Damage.

Cytotoxins - toxicity.

Nitric Oxide - adverse effects.

Catalysis.

Marmota.

Metalloporphyrins.

Sulfotransferases.

Hemoglobins - analysis.

DNA Adducts - analysis.

Tobacco.

Carcinogenesis.

Neoplasms - epidemiology.

Ligands.

Coordination Complexes - analysis.

Cations - analysis.

Food Analysis.

Tocopherols - antagonists & inhibitors.

Tobacco, Smokeless - analysis.

Hydrogen-Ion Concentration.

Mutagens - chemistry.

Adenocarcinoma.

Esophageal Neoplasms.

Rats.

Ethanol.

Allyl Compounds.

Sulfides.

Guanine.

Methylnitrosourea.

Mass Spectrometry.

Decapodiformes - chemistry.

Chromatography, High Pressure Liquid.

Photolysis.

Luminescence.

Malus - chemistry.

American Chemical Society. Division of Agricultural and Food Chemistry, sponsoring body.

American Chemical Society. Meeting (204th : 1992 : Washington, D.C.)