Distributed in print by Oxford University Press.

Description based on publisher-supplied information and home-page.

Parameters for pesticide quantitative structure activity relationships and physiologically-based pharmacokinetic and pharmacodynamic models for human risk assessment

ACS symposium series archive 1949-2017.

Original

Online version

ACS symposium series, 1099

Parameters for Pesticide QSAR and PBPK/PD Models To Inform Human Risk Assessments / Goldsmith, M. R., National Exposure Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA; Johnson, J. C., National Exposure Research Laboratory, U.S. Environmental Protection Agency, Las Vegas, Nevada 89119, USA; Chang, D. T., National Exposure Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA; Tornero-Velez, R., National Exposure Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA; Knaak, J. B., Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, SUNY at Buffalo, Buffalo, New York 14214, USA; Dary, Curtis C., National Exposure Research Laboratory, U.S. Environmental Protection Agency, Las Vegas, Nevada 89119, USA / http://dx.doi.org/10.1021/bk-2012-1099.ch001

Chiral Chemistry and Toxicity Assessments for Pyrethroid Pesticides / Gerlach, Robert W. / http://dx.doi.org/10.1021/bk-2012-1099.ch002

Direct Chiral Separation of Pyrethroid Isomers by HPLC with Chiral Stationary Phases / Okamoto, Masahiko / http://dx.doi.org/10.1021/bk-2012-1099.ch003

Biotransformation and Enzymes Responsible for Metabolism of Pyrethroids in Mammals / Kaneko, Hideo / http://dx.doi.org/10.1021/bk-2012-1099.ch004

The Influence of Maturation on Rat and Human Physiological Processes Involving Protein and Lipoprotein Binding, Gastrointestinal Absorption, and Blood Brain Permeability and Transport of Pyrethroids / Bruckner, J. V., College of Pharmacy, University of Georgia, Athens, Georgia 30602; Osmitiz, T. G., Science Strategies, Charlottesville, Virginia 22902; Anand, S., Dupont Haskell Laboratories, Newark, New Jersey 19714; Minnema, D., Syngenta Crop Protection, Greensboro, North Carolina 27419; Schmitt, W., Bayer Crop Sciences, 40789 Monheim, Germany; Assaf, N., Valent Biosciences, Libertyville, Illinois 60048; Zastre, J., College of Pharmacy, University of Georgia, Athens, Georgia 30602 / http://dx.doi.org/10.1021/bk-2012-1099.ch005

15 Factors of Percutaneous Penetration of Pesticides / Ngo, Mai A., Department of Pesticide Regulation, California Environmental Protection Agency, 1001 "I" Street, P.O. Box 4015, Sacramento, California 95812; Maibach, Howard I., Department of Dermatology, University of California, 90 Medical Center Way, Surge 110, Box 0989, San Francisco, California 94143-0989 / http://dx.doi.org/10.1021/bk-2012-1099.ch006

Mechanisms of Percutaneous Absorption of Pesticide Formulations / Reifenrath, William G. / http://dx.doi.org/10.1021/bk-2012-1099.ch007

Human Metabolic Interactions of Pesticides: Inhibition, Induction, and Activation / Hodgson, Ernest; Wallace, Andrew D. / http://dx.doi.org/10.1021/bk-2012-1099.ch008

Paraoxonase 1 (PON1) Status in Risk Assessment for Organophosphate Exposure and Pharmacokinetics / Furlong, Clement E., Departments of Medicine (Division of Medical Genetics) and Genome Sciences, University of Washington, Seattle, Washington 98195; Richter, Rebecca J., Departments of Medicine (Division of Medical Genetics) and Genome Sciences, University of Washington, Seattle, Washington 98195; Costa, Lucio G., Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98195; Jarvik, Gail P., Departments of Medicine (Division of Medical Genetics) and Genome Sciences, University of Washington, Seattle, Washington 98195 / http://dx.doi.org/10.1021/bk-2012-1099.ch009

Carboxylesterases: A Multifunctional Enzyme Involved in Pesticide and Lipid Metabolism / Ross, Matthew K., Center for Environmental Health Sciences, Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, P.O. Box 6100, Mississippi State, Mississippi 39762; Edelmann, Mariola J., Institute for Genomics, Biocomputing and Biotechnology, Mississippi Agricultural and Forestry Experimental Station, Mississippi State University, Mississippi State, Mississippi 39762 / http://dx.doi.org/10.1021/bk-2012-1099.ch010

Behavioral Changes in Adult and Young Rats as Indications of Cholinesterase Inhibition / Moser, Virginia C. / http://dx.doi.org/10.1021/bk-2012-1099.ch011

Comparison of Esterase Sensitivity, Metabolic Efficiency, and Toxicity Levels of Two Organophosphorus Insecticides: Parathion and Chlorpyrifos / Chambers, Janice E., Center for Environmental Health Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, Mississippi 39762; Meek, Edward C., Center for Environmental Health Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, Mississippi 39762; Chambers, Howard W., Center for Environmental Health Sciences, Department of Biochemistry, Molecular Biology, Entomology and Plant Pathology, Mississippi State University, Mississippi State, Mississippi 39762 / http://dx.doi.org/10.1021/bk-2012-1099.ch012

Regional Brain Dosimetry for the Organophosphorus Insecticide Chlorpyrifos in the Preweanling Rat / Timchalk, Charles, Pacific Northwest National Laboratory, 902 Battelle Blvd., P.O. Box 999, Richland, Washington 99352; Smith, Jordan Ned, Pacific Northwest National Laboratory, 902 Battelle Blvd., P.O. Box 999, Richland, Washington 99352; Hjerpe, Andrea, Pacific Northwest National Laboratory, 902 Battelle Blvd., P.O. Box 999, Richland, Washington 99352; Poet, Torka S., Pacific Northwest National Laboratory, 902 Battelle Blvd., P.O. Box 999, Richland, Washington 99352; Lee, Sookwang, Pacific Northwest National Laboratory, 902 Battelle Blvd., P.O. Box 999, Richland, Washington 99352, Current Affiliation: Food and Drug Administration (FDA), 60 Eighth St., Atlanta, Georgia 30309 / http://dx.doi.org/10.1021/bk-2012-1099.ch013

Pyrethroid Actions on Sodium Channels: Isoform and Species Specificity / Soderlund, David M. / http://dx.doi.org/10.1021/bk-2012-1099.ch014

Extrapolating Dose in Vitro to Dose in Vivo of a Neurotoxic Pyrethroid Pesticide Using Empirical Approaches and a PBPK Model / Hughes, Michael F., U.S. Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, MD B105-03, Research Triangle Park, North Carolina 27711; Chan, Melissa P. L., National Institute of Environmental Health Sciences, National Toxicology Program, P.O. Box 12233, Research Triangle Park, North Carolina 27709, Current Address: Southern Illinois University-Edwardsville, Environmental Sciences Program, Box 1099, Edwardsville, Illinois 62026; Starr, James M., U.S. Environmental Protection Agency, Office of Research and Development, National Exposure Research Laboratory, MD D205-05, Research Triangle Park, North Carolina 27711; Shafer, Timothy J., U.S. Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, MD B105-03, Research Triangle Park, North Carolina 27711; Scollon, Edward J., U.S. Environmental Protection Agency, Office of Chemical Safety and Pollution Prevention, Office of Pesticide Programs, 1200 Pennsylvania Avenue NW, MD 7509P, Washington, DC 20460; DeVito, Michael J., National Institute of Environmental Health Sciences, National Toxicology Program, P.O. Box 12233, Research Triangle Park, North Carolina 27709 / http://dx.doi.org/10.1021/bk-2012-1099.ch015

In Silico Strategies for Modeling Stereoselective Metabolism of Pyrethroids / Chang, Daniel T., National Exposure Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA; Goldsmith, Michael-Rock, National Exposure Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA; Tornero-Velez, Rogelio, National Exposure Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA; Tan, Yu-Mei, National Exposure Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA; Grulke, Christopher M., National Exposure Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA; Chen, Ling-Jen, ManTech Environmental Technology, Inc., Research Triangle Park, North Carolina 27709, USA; Ulrich, Elin M., National Exposure Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA; Lindstrom, Andrew B., National Exposure Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA; Pasquinelli, Melissa A., North Carolina State University, Raleigh, North Carolina 27695, USA; Rabinowitz, James R., National Center for Computational Toxicology, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA; Dary, Curtis C., National Exposure Research Laboratory, U.S. Environmental Protection Agency, Las Vegas, Nevada 89119, USA / http://dx.doi.org/10.1021/bk-2012-1099.ch016

Quantitative Structure-Activity Relationships for Organophosphate Enzyme Inhibition / Ruark, Christopher D.; Hack, C. Eric; Robinson, Peter J.; Gearhart, Jeffery M. / http://dx.doi.org/10.1021/bk-2012-1099.ch017

Computational Approaches for Developing Informative Prior Distributions for Bayesian Calibration of PBPK Models / Davis, Jimena L., National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, 109 T.W. Alexander Drive, Research Triangle Park, North Carolina 27711; Tornero-Velez, Rogelio, National Exposure Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, 109 T.W. Alexander Drive, Research Triangle Park, North Carolina 27711; Setzer, R. Woodrow, National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, 109 T.W. Alexander Drive, Research Triangle Park, North Carolina 27711 / http://dx.doi.org/10.1021/bk-2012-1099.ch018

Use of Cytochrome P450-Specific Parameters and Human Biomarker Data To Develop a Human Physiologically Based Pharmacokinetic/Pharmacodynamic Model for Dermal Chlorpyrifos Exposure / Ellison, Corie A., Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, SUNY at Buffalo, 3435 Main Street, Buffalo, New York 14214; Knaak, James B., Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, SUNY at Buffalo, 3435 Main Street, Buffalo, New York 14214; McDougall, Robin, Faculty of Engineering and Applied Science, University of Ontario Institute of Technology, 2000 Simcoe Street North, Oshawa, Ontario L1H 7K4, Canada; Olson, James R., Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, SUNY at Buffalo, 3435 Main Street, Buffalo, New York 14214 / http://dx.doi.org/10.1021/bk-2012-1099.ch019

Use of in Vitro Data in PBPK Models: An Example of in Vitro to in Vivo Extrapolation with Carbaryl / Yoon, Miyoung, Center for Human Health Assessment, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709; Kedderis, Gregory L., Independent Consultant, Chapel Hill, North Carolina 27516; Yang, Yuching, Center for Human Health Assessment, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709; Allen, Bruce C., Bruce Allen Consulting, Chapel Hill, North Carolina 27514; Yan, Grace Z., Center for Human Health Assessment, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709; Clewell, Harvey J., Center for Human Health Assessment, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709 / http://dx.doi.org/10.1021/bk-2012-1099.ch020

Editors' Biographies / http://dx.doi.org/10.1021/bk-2012-1099.ot001

Pesticides > Risk assessment.

Pesticides > Health risk assessment.

Pyrethroids > Toxicity testing.

Pyrethroids > Metabolism.

Pyrethroids > Transport properties.

Skin absorption > Mechanism of action.

Pesticides > Absorption and adsorption > Mechanism of action.

Pesticides > Metabolism.

Organophosphorus compounds > Risk assessment.

Esterases > Metabolism.

Cholinesterases > Health risk assessment.

Parathion > Risk assessment.

Chlorpyrifos > Risk assessment.

Chlorpyrifos > Health risk assessment.

Sodium channels > Effect of pesticides on.

Neurotoxic agents > Toxicity testing.

Pyrethroids > Metabolism > Models.

Organophosphorus compounds > Structure-activity relationships.

Enzyme inhibitors > Structure-activity relationships.

Pharmacokinetics > Models.

Chlorpyrifos > Toxicology > Models.

Carbaryl > Toxicology > Models.

Pesticides - toxicity.

Models, Chemical.

Pharmacokinetics.

Quantitative Structure-Activity Relationship.

Risk Assessment.

Pesticides.

Pyrethrins.

Toxicity Tests.

Stereoisomerism.

Pyrethrins - metabolism.

Skin Absorption.

Pesticides - pharmacokinetics.

Pesticides - metabolism.

Organophosphorus Compounds.

Esterases - metabolism.

Cholinesterases.

Parathion.

Chlorpyrifos.

Cholinesterase Inhibitors.

Insecticides.

Sodium Channels.

Pesticides - adverse effects.

Neurotoxins.

Models, Theoretical.

Organothiophosphorus Compounds.

Structure-Activity Relationship.

Enzyme Inhibitors.

Bayes Theorem.

Chlorpyrifos - toxicity.

Carbaryl - toxicity.

American Chemical Society. Division of Agrochemicals, sponsoring body.