9781394175482

1394175485

9781394174683

9781394175468

1394175469

9781394175475

1394175477

1394174683

Electronic reproduction. Hoboken, N.J. Available via World Wide Web.

Description based on online resource; title from digital title page (viewed on February 28, 2024).

Preface

Part 1 General

1 History of Nanoparticles 3 Keshava L. Jetha, Arya Vyas, Divya Teli, Amit Chaudhari, Riyansi Satasiya, Vishwa Patel, Shailvi Soni, Shail Modi and Vasso Apostolopoulos

1.1 Introduction

1.2 History of Nanoparticles

1.3 Modern Development of Nanoparticles

1.4 Type of Nanoparticles

1.5 Properties of Nanoparticles

1.6 Importance of Nanoparticles

1.7 Conclusion and Future Prospect

2 Composition of Nanoparticles 25 Amit Chaudhari, Palak Vadodariya, Arya Vyas, Disha Patel and Divya Teli

2.1 Introduction

2.2 Types of Nanoparticles

2.3 Composition of Nanoparticles

2.4 Synthesis of Nanoparticles

2.5 Nanoparticle Characterization by Various Instrumental Techniques

2.6 Understanding Nanotoxicity: Potential Risks and Implications

2.7 Conclusion

3 Nanotechnology and Vaccine Development 63 Keshava L. Jetha, Praful D. Bharadia and Manish P. Patel

3.1 Introduction

3.2 Overview of Vaccine Development

3.3 Advantages of Nanoparticles in Vaccine Delivery

3.4 Types of Nanoparticles as Vaccine Carriers

3.5 Development of Nanoparticle-Based Vaccine

3.6 Adjuvants and their Role in Vaccine Development

3.7 Nanoscale Adjuvants

3.8 Advantages

3.9 Techniques for Nanoscale Adjuvants

3.10 Route of Administration for Vaccines

3.11 Recent Advances in Nanotechnology-Based Vaccines

3.12 The Regulatory Perspective of Nanoparticle-Based Vaccine Development

3.13 Future Prospects

3.14 Conclusion

4 Nanoparticle Formulations: A Sustainable Approach to Biodegradable and Non-Biodegradable Products 95 Amandeep Singh, Shreni Parikh, Nutan Sethi, Sachin Patel, Nrupal Modi and Kaushika Patel

4.1 Introduction

4.2 Types of Nanoparticles

4.3 Preparation of Nanoparticles

4.4 Factors Affecting Selection of Method

4.5 Polymers Used in NP Formulation

4.6 Nanoparticle Formulations Based on Biodegradable Polymers

4.7 Nanoparticle Formulations Based on Non-Biodegradable Polymers

4.8 Nanoparticle Formulations Based on Natural Polymers

4.9 Challenges in NPs from Laboratory to Industrial Scale-Up

4.10 Nanoparticle-Based Approved & Marketed Formulations

4.11 Future Aspects & Conclusion

5 Nanoparticle Properties: Size, Shape, Charge, Inertness, Efficacy, Morphology 153 Kajal P. Baviskar, Brijesh M. Shah, Anjali P. Bedse, Shilpa S. Raut, Suchita P. Dhamane and Dhara J. Dave

5.1 Introduction

5.2 Applications of Nanoparticle Formulations

5.3 Interaction with Cells

5.4 Properties of Nanoparticles

5.5 Role of Physicochemical Properties in Nanoparticle Toxicity

5.6 Conclusion

Part 2 Nanoparticles to Deliver Antigen

6 Viral Vector-Based Nanoparticles 195 Suneetha Vuppu, Vivek P. Chavda, Toshika Mishra, Oishani Sengupta, Anand Sairam, Paridhi Soni, Mohit Joshi, Bhumi Bhalodiya and Raj

6.1 Introduction

6.2 Characteristics of Viral Vector-Based Nanoparticles

6.3 Applications

6.4 Novel Advancements in Applications of Viral Nanoparticles

6.5 Limitations and Prospects of Viral Vector-Based Nanoparticle Approach

6.6 Conclusion

7 Lipid-Based Nanoparticles 241 Sunny Shah, Hardik Madhu, Moinuddin Soniwala, Dhaval Mori, Amit Vyas, Advaita Chauhan and Bhupendra Prajapati

7.1 Introduction

7.2 Types of Lipid-Based Nanoparticles

7.3 Synthesis of Lipid-Based Nanoparticles

7.4 Characterization of Lipid Nanoparticles

7.5 Applications of Lipid-Based Nanoparticles in Vaccines

7.6 Challenges and Future Directions

7.7 Conclusion

8 Nanoparticle-Based mRNA Vaccines: Are We One Step Closer to Targeted Cancer Therapy? 275 Lakshmi Vineela Nalla, Siva Nageswararao Gajula and Vivek P. Chavda

8.1 Introduction

8.2 Use of mRNA in Vaccines: Advantages and Challenges

8.3 How Do mRNA Vaccines Work?

8.4 Nanocarriers for mRNA Delivery

8.5 Nanoparticle-Based mRNA Vaccines in Cancer Therapy

8.6 Clinical Trials

8.7 Conclusion

9 Protein Delivery by Nanoparticles 305 Harshita Gauraha, Ankita Bhadoriya, Rupesh K. Gautam and Dinesh Kumar Mishra

9.1 Introduction

9.2 Major Challenges in Protein Delivery

9.3 Nanotechnology

9.4 Nanoparticles

9.5 Methods of Preparation

9.6 Nanoformulations Available for Protein and Peptide Delivery

9.7 Clinical Trials and Market-Approved Nanoparticles

9.8 Characterization of Protein Nanoparticles

9.9 Applications of Protein Nanoparticles

9.10 Conclusion

9.11 Future Developments

Part 3 Route of Administration

10 Oral Vaccine Delivery: Current Status 347 Pankti C. Balar, Vidhi A. Modh, Sanjay P. Chauhan, Hetvi K. Solanki, Rajeshkumar K. Patel, Dasharath M. Patel and Maharshi B. Padya

10.1 Introduction

10.2 Need for Oral Vaccines

10.3 Nanoparticles as an Oral Vaccine Delivery System

10.4 Advantages of Oral Nanovaccines

10.5 Drawbacks and Disadvantages of Oral Nanovaccines

10.6 Barriers in Oral Vaccines Delivery

10.7 Currently Licensed Oral Vaccines

10.8 Descriptions of Licensed Oral Vaccines

10.9 Conclusion and Future Prospect

11 Nanovaccines for Mucosal Immunity 367 Shashi Kiran Misra, Anupria Kapoor and Kamla Pathak

11.1 Introduction

11.2 Mucosal Immunity

11.3 Nanovaccine Formulations

11.4 Future Perspectives

11.5 Conclusion

12 Nanovaccine via Intramuscular, Subcutaneous, and Intradermal Routes 405 Dixa A. Vaghela, Maharshi Bhailalbhai Pandya, Pooja M. Parmar, Sanjay P. Chauhan, Akta Vaishnav, Rajeshkumar K. Patel, Dasharath M. Patel, Vidhi Ankit Modh and Mihir K. Raval

12.1 Introduction

12.3 Introduction to the Route of Administration

12.4 Comparable Adaptive Immune Response After IM, SC, and ID Routes

12.5 Marketed Formulation

12.6 Challenges of Vaccine Delivery

12.7 Conclusion

Part 4 Application and Advances

13 Nanovaccines for Veterinary Applications 425 Suneetha Vuppu, Vivek P. Chavda, Toshika Mishra, Swati Punetha, Nikita Sharma, Sathvika Kamaraj and Raj

13.1 Introduction

13.2 Nanovaccines and Immune Response

13.3 Vaccine Production

13.4 Veterinary Applications of Nanovaccines

13.5 Comparative Analysis of Animal Vaccines, Nanovaccines, and Edible Vaccines

13.6 Regulation of Vaccine Production Process

13.7 New Approaches

13.8 Applications of Different Polymer-Based Nanoparticles

13.9 Future Prospects

13.10 Conclusion

14 Regulatory Pathways for Nanocarrier Vaccine 465 Niva Rani Gogoi, Rajashri Bezbaruah, Vishwa Patel, Riyansi Satasia, Bedanta Bhattacharjee and Bhaskar Mazumder

14.1 Introduction

14.2 The Need for a Regulatory Framework

14.3 Regulatory Requirements for the Manufacturing of NVs

14.4 Clinically Approved Nanocarrier Vaccines

14.5 Regulatory Challenges

14.6 Global Strategies for Clinical Approval

14.7 Conclusion and Future Prospects

References

Index.

Wiley InterScience (Online service)