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Drugs from Nature: Targets, Assay Systems and Leads

Title
Drugs from Nature: Targets, Assay Systems and Leads [electronic resource] / edited by Madhathilkovilakathu Haridas, Sabu Abdulhameed, Dileep Francis, Swaroop S Kumar.
ISBN
9789819991839
Edition
1st ed. 2024.
Publication
Singapore : Springer Nature Singapore : Imprint: Springer, 2024.
Physical Description
1 online resource (XIV, 568 p.) 1 illus.
Local Notes
Access is available to the Yale community.
Access and use
Access restricted by licensing agreement.
Summary
This book provides an overview of the drug discovery process from natural sources such as plants and microbes. While technological advances have streamlined the drug discovery process, enhancing the throughput and success rates, the structural features of natural products remain the primary reference for small-molecule drug discovery. Focusing on the drug targets blocked/altered by natural/nature-inspired molecules, it covers how potential drug leads are screened and identified using appropriate assay systems, and the current status of drugs identified using such approaches. State-of-the-art approaches in target identification, assay development, and lead identification have also been discussed in detail. Other topics included are targets and leads in inflammation, cancer, reproductive medicine, cardiovascular and neuromuscular ailments, and infectious diseases as well as the challenges in translating drug leads into clinically viable drugs. This volume serves as a handbook for researchers in phytochemistry and drug discovery, and as a reference for researchers and students of applied biology.
Variant and related titles
Springer ENIN.
Other formats
Printed edition:
Printed edition:
Printed edition:
Format
Books / Online
Language
English
Added to Catalog
April 10, 2024
Contents
Chapter 1. History of therapeutic discovery from natural sources
Chapter 2. The process of drug development from natural sources
Chapter 3. Ayurveda-inspired reverse pharmacology in drug discovery
Chapter 4. Contemporary approaches in drug target identification and validation
Chapter 5. Assay systems for identification of drug leads: contemporary approaches
Chapter 6. Computational biology in lead identification and drug development
Chapter 7. Physiology of inflammatory responses to external and autoimmune agents of diseases
Chapter 8. Non-steroidal anti-inflammatory drug leads from natural sources
Chapter 9. Mechanisms of side effects of non-steroidal anti-inflammatory drugs
Chapter 10. Therapeutic targets in cancer
Chapter 11. Anti-neoplastic drug leads from plants and microbes
Chapter 12. Anti-fungal, anti-bacterial, and anti-parasitic therapeutics from natural sources
Chapter 13. Anti-viral therapeutics from plants and microbes
Chapter 14. Cardiovascular therapeutics from natural sources
Chapter 15. Antidiabetics and antilipemics from nature
Chapter 16. Therapeutic targets and drug leads for reproductive health
Chapter 17. Drug leadsfor neuro-muscular disorders from natural sources.
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