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Antimicrobial Resistance: Factors to Findings Omics and Systems Biology Approaches
Title
Antimicrobial Resistance: Factors to Findings [electronic resource] : Omics and Systems Biology Approaches / edited by Vijay Soni, Ajay Suresh Akhade.
ISBN
9783031659867
Edition
1st ed. 2024.
Publication
Cham : Springer International Publishing : Imprint: Springer, 2024.
Physical Description
1 online resource (XV, 454 p.) 43 illus., 42 illus. in color.
Local Notes
Access is available to the Yale community.
Access and use
Access restricted by licensing agreement.
Summary
Antimicrobial resistance (AMR) is increasing globally at an incredible rate, and many infectious diseases have already reached an alarming stage of resistance to existing treatments. WHO reports that nearly1.27 million people currently die each year due to resistant infections, and AMR is projected to account for 10 million annual deaths globally by 2050. There is an urgent need for novel approaches to address this issue. Omics technologies are powerful research tools used extensively to study pathogen biology and the activity of microbial agents. These tools, paired with systems biology approaches, can provide novel insights into antimicrobial susceptibility and resistance, and aid in the development of new, more effective measures to combat resistant pathogens. This book provides a comprehensive overview of omics technologies to study pathogen biology, including proteomics, genomics, transcriptomics, metabolomics, and microbiome analysis, and the role of systems biology in developing strategies to combat resistant pathogens. It addresses environmental reservoirs and mobile genetic agents in AMR, host-pathogen interactions and physiology in the development of resistance, drug repurposing and development, and cutting-edge tools such as machine learning, AI for big data analysis, and genomic surveillance. The final section discusses future perspectives on omics-systems biology in AMR, and identifies opportunities for scientific collaboration in the global fight against antimicrobial resistance. This book serves as a comprehensive and accessible resource for researchers in academia and industry focused on immunology, drug development, biotechnology, and systems biology.
Variant and related titles
Springer ENIN.
Other formats
Printed edition:
Printed edition:
Printed edition:
Format
Books / Online
Language
English
Added to Catalog
October 14, 2024
Contents
Antimicrobial resistance and factors
Genomics as a tool to track global AMR
Meta-transcriptomics to reveal mechanisms of drug action and resistance
Use of proteomics to study bacterial virulence and AMR
Metabolomics to understand bacterial and drug metabolism
Microbiome and AMR: A One Health perspective
Environmental reservoirs, genomic epidemiology, and mobile genetic elements
Multiomics approach to control AMR
Systems biology and AMR
Host-directed omics approaches to control AMR
Role of AI and Machine Learning in omics analysis of AMR evolution and surveillance
Drug discovery and AMR treatments using an omics-based approach
Future perspectives of omics-systems biology to control AMR: Recommendations and future directions.
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