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Chemical biology : the role of chemistry in our fundamental understanding of biology,

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Contents: HIV-1 protease

Electronic properties of the catalytic apparatus

Defining the 'aspartyl proteases'

'Backbone engineering' HIV-1 PR

The alpha-helix

Ubiquitin (76 aa)

Conformation vs. solvation effects

Global and local structures are highly conserved

Stability measurements of [Aaa35] ubiquitins

Energetic contributions at helix C' position

Erythropoietin (Epo)

Synthetic erythropoiesis protein

Synthetic 'glycan mimetic'

Glycoprotein synthesis

Molecular basis of protein function

The synthetic challenge

Classical solution synthesis

Stepwise solid-phase synthesis

Chemical protein synthesis

Unprotected peptides

Principles of chemical ligation

Thioester-forming ligation

Total synthesis of D- & L-HIV-1 protease

Crystal structure of D-HIV-1 protease

Native chemical ligation

Crambin (46 aa; 6 Cys)

CPS: current challenges.