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Stem Cell Biology in Neoplasms of the Central Nervous System
Author
Title
Stem Cell Biology in Neoplasms of the Central Nervous System [electronic resource] / edited by Moneeb Ehtesham.
ISBN
9783319165370
Publication
Cham : Springer International Publishing : Imprint: Springer, 2015.
Physical Description
XIII, 190 p. 16 illus., 15 illus. in color : online resource.
Local Notes
Access is available to the Yale community.
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Access restricted by licensing agreement.
Summary
This volume presents the most current reviews on how cancer stem cells (CSCs) hypothesis dictates that the continued proliferation of a tumor is dependent on a sub-population of self-renewing and asymmetrically dividing neoplastic stem cells that supply a largely differentiated tumor. This volume provides a comprehensive overview of the characteristics of CSCs, their role in central nervous system (CNS) tumors, and the recent CSC-specific treatment modalities being used. The emerging focus on CSCs in brain tumors represents a paradigm shift in our understanding of the pathogenesis of these neoplasms. Importantly, the realization that a distinct sub-population of cells contributes disproportionately to the growth and sustenance of central nervous system tumors has important implications for the treatment of such tumors. To treat CNS tumors, there is now a growing need to treat CSCs to achieve adequate tumor control.
Variant and related titles
Springer ebooks.
Other formats
Printed edition:
Format
Books / Online
Language
English
Added to Catalog
May 04, 2015
Series
Advances in Experimental Medicine and Biology, 853
Contents
Regulation of Subventricular Zone-Derived Cells Migration in the Adult Brain
The SVC and Its Relationship to Stem Cell Based Neuro-oncogenesis. - Isolation and characterization of stem cells for human central nervous system malignancies. - The role of stem cells in pediatric central nervous system malignancies. - Laboratory models for central nervous system tumor stem cell research. - Radiation Therapy for Glioma Stem Cells
Chemoresistance and chemotherapy targeting stem-like cells in malignant glioma
Immunobiology and Immunotherapeutic targeting of glioma stem cells
Emerging strategies for the treatment of tumor stem cells in central nervous system malignancies.
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