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Biomedical Applications of Acridines Derivatives, Syntheses, Properties and Biological Activities with a Focus on Neurodegenerative Diseases

Title
Biomedical Applications of Acridines [electronic resource] : Derivatives, Syntheses, Properties and Biological Activities with a Focus on Neurodegenerative Diseases / by Jan Ježek, Jan Hlaváček, Jaroslav Šebestík.
ISBN
9783319639536
Publication
Cham : Springer International Publishing : Imprint: Springer, 2017.
Physical Description
XIII, 237 p. 79 illus., 25 illus. in color : online resource.
Local Notes
Access is available to the Yale community.
Access and use
Access restricted by licensing agreement.
Summary
This book describes applications of acridines for the treatment of various neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and various prion diseases, and discusses the potential of acridines in neuro-regenerative medicine. Using modern data-mining software, it presents structures of acridines with nucleic acids and proteins and compares them with the native structures. Furthermore, the book presents modern methods of acridine synthesis, comparing them with the most useful conventional methods. Acridines interact with both nucleic acids and proteins, and due to their direct interactions with various enzymes, they can be suitable for the treatment of neurodegenerative diseases, inflammation, immunological disorders, and protozoal diseases. The characteristic spectral properties of acridines can be employed in labeling proteins, nucleic acids, lipids, and even cells and their compartments. Moreover, they can be applied in photodynamic therapy.
Variant and related titles
Springer ebooks.
Other formats
Printed edition:
Format
Books / Online
Language
English
Added to Catalog
September 05, 2017
Series
Progress in drug research ; 72.
Progress in Drug Research, 72
Contents
Preliminary ToC 1 Introduction
2 Nomenclature
3. Syntheses
4. Interactions of acridines with nucleic acids
5. Intercations with proteins
6. Applications for treament of neurodegenerative diseases
7. Some applications of selective toxicities of acridines
8. Acridine on dendrimeric carriers
9 Acridines used for staining
10 Miscellaneous
11 Conclusions and outlook.
Citation

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