Title
Immunotherapy of Hepatocellular Carcinoma [electronic resource] / edited by Tim F. Greten.
Publication
Cham : Springer International Publishing : Imprint: Springer, 2017.
Physical Description
1 online resource (X, 167 p. 19 illus., 15 illus. in color.)
Local Notes
Access is available to the Yale community.
Access and use
Access restricted by licensing agreement.
Summary
In this book we provide insights into liver – cancer and immunology. Experts in the field provide an overview over fundamental immunological questions in liver cancer and tumorimmunology, which form the base for immune based approaches in HCC, which gain increasing interest in the community due to first promising results obtained in early clinical trials. Hepatocellular carcinoma (HCC) is the third most common cause of cancer related death in the United States. Treatment options are limited. Viral hepatitis is one of the major risk factors for HCC, which represents a typical “inflammation-induced” cancer. Immune-based treatment approaches have revolutionized oncology in recent years. Various treatment strategies have received FDA approval including dendritic cell vaccination, for prostate cancer as well as immune checkpoint inhibition targeting the CTLA4 or the PD1/PDL1 axis in melanoma, lung, and kidney cancer. Additionally, cell based therapies (adoptive T cell therapy, CAR T cells and TCR transduced T cells) have demonstrated significant efficacy in patients with B cell malignancies and melanoma. Immune checkpoint inhibitors in particular have generated enormous excitement across the entire field of oncology, providing a significant benefit to a minority of patients. .
Variant and related titles
Springer ebooks.
Other formats
Printed edition:
Added to Catalog
November 02, 2017
Contents
Preface
Introduction
Vaccine approaches
Spontaneous Immune responses to ablative therapies
Antigen-specific T cell responses. Immune checkpoint inhibitors
NASH and HCC
Cytokine activated killer cells
Sorafenib combination therapy
Glypican 3
Suppressor cells
Cytokines in HCC pathogenesis and treatment
Index.
Also listed under
SpringerLink (Online service)