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Growth factors and their receptors in cell differentiation, cancer and cancer therapy
Author
Title
Growth factors and their receptors in cell differentiation, cancer and cancer therapy / G.V. Sherbet.
ISBN
9780123878205
0123878209
9780123878199
0123878195
Edition
1st ed.
Published
Amsterdam ; Boston : Elsevier, 2011.
Physical Description
1 online resource (xix, 347 pages) : illustrations.
Local Notes
Access is available to the Yale community.
Access and use
Access restricted by licensing agreement.
Summary
Recent years have seen a considerable emphasis on growth factors and the elucidation of their mode of function, which has led to the recognition that growth factors, their receptors as well as downstream elements of signalling associated with their function might be potential targets in therapeutic management of human diseases. Humanised monoclonal antibodies raised against growth factor receptors have proved to be valuable for targeted cancer treatment and in patient management. This book reviews the latest developments providing insights into the signalling processes involved in morphogenesis and pathogenesis with emphasis on using the elements of the signalling cascades as targets for therapeutic deployment. Provides a fundamental understanding of the basic functions of growth factors and their receptors, describing how they are linked in biological processes. Aids the development of therapeutic treatments for cancer. Focuses on the interrelationships and convergence of growth factors and their receptors in development and pathogenesis and encourages greater cooperation and integration in the areas of developmental, cancer and cancer therapeutic research.
Variant and related titles
Elsevier ScienceDirect All Books. OCLC KB.
Other formats
Print version: Sherbet, G.V. (Gajanan V.). Growth factors and their receptors in cell differentiation, cancer and cancer therapy. 1st ed. Amsterdam ; Boston : Elsevier, 2011
Format
Books / Online
Language
English
Added to Catalog
May 17, 2018
Series
Elsevier insights
Bibliography
Includes bibliographical references (pages 249-347).
Contents
Convergence of growth-factor signalling pathways in developmental systems and pathogenesis
Growth factor families
Growth factors in differentiation and morphogenesis
Vascular endothelial growth factor
Hepatocyte growth factor
Platelet-derived growth factor family
Nerve growth factors
Insulin-like growth factors
Connective tissue growth factors
Thrombospondins
Cytokines
Growth factor and hedgehog signalling pathways meet in developmental systems
Epidermal growth factors and their signalling systems
Epidermal growth factor (EFG) family
Fibroblast growth factor family
Intracellular receptor building growth factors
Androgens and androgen receptors in development, differentiation and neoplasia
Vitamin D₃ in cell proliferation, apoptosis and differentiation
Retinoids in development and pattern formation
Oestrogens and progesterone in normal physiology and neoplasia
Glucocorticoid signalling in normal and aberrant physiology.
Subjects
Subjects (Medical)
Intercellular Signaling Peptides and Proteins - metabolism.
Receptors, Growth Factor - metabolism.
Cell Differentiation.
Neoplasms - etiology.
Neoplasms - therapy.
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