0128016132

9780128016138

9780128013809

012801380X

Current topics in developmental biology ; volume 122

Front Cover; T-box Genes in Development; Copyright; Contents; Contributors; Preface; References; Chapter One: Evolution and Classification of the T-Box Transcription Factor Family; 1. An Updated Phylogenetic Classification of the T-Box Gene Family; 2. Premetazoan T-Box Genes; 3. Metazoan T-Box Classes and Function; 3.1. Brachyury; 3.2. Eomes/Tbrain; 3.3. Tbx7; 3.4. Tbx8; 3.5. Tbx2/3; 3.6. Tbx4/5; 3.7. Tbx1/15/20; 3.8. Tbx6; 4. Functional Conservation of Premetazoan and Early-Metazoan Brachyury Homologs; 5. Ancestral Conserved Role of Brachyury in Morphogenetic Movements.

6. The Evolution of T-Box RegulationAcknowledgments; References; Chapter Two: The Remarkably Diverse Family of T-Box Factors in Caenorhabditis elegans; 1. Introduction; 2. T-Box Genes in C. elegans and Related Nematodes; 3. DNA-Binding Specificity of C. elegans T-Box Factors; 4. Genetic Analyses of T-Box Factor Function in C. elegans; 4.1. A Network of T-Box Factors Function in C. elegans Pharyngeal Development; 4.2. tbx-2 Has Additional Functions in Neuronal Development and Sensory Adaptation.

4.3. The Tbx-1 Subfamily Members MAB-9 and MLS-1 Function Postembryonically to Specify Ectodermal and Muscle Cell Fates4.4. The TBX-8 and TBX-9 Paralogs Play Redundant Roles in Hypodermal and Body Wall Muscle Morphogenesis; 4.5. The Divergent T-Box Factor SEA-1 Functions as an Autosomal Counting Element to Determine Sex in C. elegans; 4.6. The Functions of Other C. elegans T-Box Genes Are Only Beginning to Be Characterized; 5. Posttranslational Mechanisms Affecting T-Box Factor Activity; 6. Concluding Remarks; Acknowledgments; References.

Chapter Three: T-Box Genes and Developmental Gene Regulatory Networks in Ascidians1. Introduction; 2. Brachyury and the Temporal Control of Notochord Specification, Development, and Differentiation; 3. Tbx2/3: An Essential Mediator of Brachyury Function in the Notochord; 4. The Lineage-Specific Duplication of Tbx6 Genes in Ascidians; 5. Tbx6a; 6. Tbx6b, Tbx6c, and the Interpretation of the Maternally Inherited Muscle Determinant; 7. Tbx6b and Tbx6c in Heart Development; 8. Tbx1/10 and the Evolutionary Origins of the Pharyngeal Muscles.

9. Tbx15/18/22 (VegTR) and the Establishment of Muscle Cell Identity10. Maternal T and Tail Development; 11. Tbx20: In or Out of the Ascidian Heart?; 12. Transcriptional Regulation of T-Box Genes Expression; 12.1. Brachyury: A Balancing Act Between Multiple Activators and a Repressor; 12.2. Tbx2/3: A Composite Expression Pattern Orchestrated by Additive, Partly Redundant CRMs; 12.3. Tbx6b and Tbx6c: Early and Late Elements, Autoregulation, and Crossregulation; 13. Concluding Remarks; Acknowledgments; References.