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High Content Screening A Powerful Approach to Systems Cell Biology and Drug Discovery
Title
High Content Screening [electronic resource] : A Powerful Approach to Systems Cell Biology and Drug Discovery / edited by D. Lansing Taylor, Jeffrey R. Haskins, Kenneth A. Giuliano.
ISBN
9781597452175
Publication
Totowa, NJ : Humana Press, 2006.
Physical Description
1 online resource (464 p.) 168 illus.
Local Notes
Access is available to the Yale community.
Access and use
Access restricted by licensing agreement.
Summary
High content screening (HCS) was developed by Cellomics Inc. in the mid-1990s to address the need for a platform that could be used in the discovery-driven research and development required to understand the functions of genes and gene products at the level of the cell. High Content Screening: A Powerful Approach to Systems Cell Biology and Drug Discovery discusses its use as a high throughput platform to understand the functions of genes, RNA, proteins, and other cellular constituents at the level of the living cell. High Content Screening is assembled to assist both existing users of HCS, as well as investigators considering the addition of a discovery-driven platform to their research and development activities. The chapters have been organized into sections that highlight the importance of integrating instrumentation, application software, reagents, and informatics. In addition, there is a combination of pure review chapters on key topics and specific methods chapters.
Variant and related titles
Springer protocols (Series)
Other formats
Printed edition:
Format
Books / Online
Language
English
Added to Catalog
August 31, 2018
Series
Methods in Molecular Biology, 356
Contents
to High Content Screening
Past, Present, and Future of High Content Screening and the Field of Cellomics
A Pharmaceutical Company User’s Perspective on the Potential of High Content Screening in Drug Discovery
Linking Microscopy and High Content Screening in Large-Scale Biomedical Research
Instrumentation, Biological Application Software, and Sample Preparation
Requirements, Features, and Performance of High Content Screening Platforms
Characteristics and Value of Directed Algorithms in High Content Screening
Characteristics and Value of Machine Learning for Imaging in High Content Screening
Tools for Quantitative and Validated Measurements of Cells
Automated Cell Plating and Sample Treatments for Fixed Cells in High Content Assays
Differentiating Primary Human Cells in Rapid-Throughput Discovery Applications
Use of the CellCard™ System for Analyzing Multiple Cell Types in Parallel
Reagents
Reagents to Measure and Manipulate Cell Functions
Fluorescent Proteins and Engineered Cell Lines
Optimizing the Integration of Immunoreagents and Fluorescent Probes for Multiplexed High Content Screening Assays
The HaloTag™
Protein Labeling With FlAsH and ReAsH
Exploiting Network Biology to Improve Drug Discovery
Physiological Indicators of Cell Function
The Use of siRNA to Validate Immunofluorescence Studies
Caged Substrates Applied to High Content Screening
Informatics and Bioinformatics
Overview of Informatics for High Content Screening
Large-Scale Data Management for High Content Screening
An Integrated Biomedical Knowledge Extraction and Analysis Platform
Visualization of High Content Screening Data
Pathway Mapping Tools for Analysis of High Content Data
Assays and Applications of High Content Screening
Systems Biology in Cancer Research
Target Validation in Drug Discovery
High Content Screening as a Screening Tool in Drug Discovery
Discovery of Protein Kinase Phosphatase Inhibitors
High Content Translocation Assays for Pathway Profiling
In Vitro Cytotoxicity Assessment
Neurite Outgrowth in Retinal Ganglion Cell Culture.
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