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Advances in Dementia Research
Title
Advances in Dementia Research [electronic resource] / edited by K. Jellinger, R. Schmidt, M. Windisch.
ISBN
9783709167816
Publication
Vienna : Springer Vienna, 2000.
Physical Description
1 online resource (VIII, 339 p.) 43 illus., 1 illus. in color.
Local Notes
Access is available to the Yale community.
Access and use
Access restricted by licensing agreement.
Summary
Dementia is a major health problem that becomes increasingly common with advancing age. Despite recent progress in neurobiology and molecular genetics, the aetiology and pathogenesis of most dementia disorders are still poorly understood, and early exact diagnosis as a prerequisite of effective treatment needs to be improved. The present volume includes the contributions of renowned experts in the field of neurodegeneration presented at the International Symposium "Ageing and Dementia 1999”, September 24–26, 1999 at Graz. It focusses on genetics, epidemiology, new neuroimaging techniques, and the role of vascular, immunological and other mechanisms including oxidative stress and estrogens in the development of neurodegeneration and dementia. Recent developments in diagnosis and therapy of Alzheimer disease and related disorders are reviewed and future therapeutic approaches are discussed. Thus, this volume provides a timely overview of most recent developments in dementia research and treatment strategies of dementia disorders.
Variant and related titles
Springer ENIN.
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Printed edition:
Format
Books / Online
Language
English
Added to Catalog
April 03, 2019
Series
Journal of Neural Transmission. Supplementa, 59
Contents
White matter changes: the clinical consequences in the aging population
Longitudinal change of white matter abnormalities
Genetic aspects of microangiopathy-related cerebral damage
Research criteria for subcortical vascular dementia in clinical trials
How can cerebral infarcts and hemorrhages lead todementia?
Vascular aspects in Alzheimer’s disease
Novel imaging technologies in the assessment of cerebral ageing and vascular dementia
Alzheimer disease and neuroinflammation
The immunological microenvironment in the CNS: implications on neuronal cell death and survival
Toxic effector molecules in the pathogenesis of immune-mediated disorders of the central nervous system
Cytokines in CNS disorders: neurotoxicity versus neuroprotection
Do neuronal inclusions kill the cell?
Mechanisms of cell death in neurodegenerative disorders
Estrogens, apoptosis and cells of neural origin
Markers of apoptosis and models of programmed cell death in Alzheimer’s disease
Mitochondrial dysfunction and oxidative stress in aging and neurodegenerative disease
Genetics of Alzheimer’s disease — routes to the pathophysiology
Secretion of the amyloid precursor protein is elevated isoform specifically by apolipoprotein E4
Alterations in neurotrophins and neurotrophin receptors in Alzheimer’s disease
Genetically altered transgenic models of Alzheimer’s disease
Morphological substrates of mental dysfunction in Lewy body disease: an update
Mechanism of neurofibrillary degeneration and pharmacologic therapeutic approach
Understanding the role of estrogen on cognition and dementia
Present and future of Alzheimer therapy
Trials to slow progression and prevent disease onset
Epidemiologic clues to the causes and routes to prevention of Alzheimer disease
Post-transcription modulation of the blood-brain barrier GLUT1 glucose transporter by brain-derived factors
A brain derived peptide preparation reduces the translation dependent loss of a cytoskeletal protein in primary cultured chicken neurons
Neurotrophic effects of Cerebrolysin® in animal models of excitotoxicity
Cerebrolysin® reduces microglial activation in vivo and in vitro: a potential mechanism of neuroprotection
Clinical experience with Cerebrolysin®
Approach towards an integrative drug treatment of Alzheimer’s disease
Oral Cerebrolysin® enhances brain alpha activity and improves cognitive performance in elderly control subjects.
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