Front Cover; Cell Fate in Mammalian Development; Copyright; Contents; Contributors; Chapter One: Introduction; Chapter Two: Cell Polarity-Dependent Regulation of Cell Allocation and the First Lineage Specification in the Preimplanta ... ; 1. Introduction; 1.1. Models for Early Lineage Specification in the Preimplantation Mouse Embryo; 1.1.1. The Inside-Outside Model; 1.1.2. The Cell Polarity Model; 2. Compaction and Polarization: Two Key Morphogenetic Events Influencing the Formation of Outer/Inner Cells
3. Asymmetric Division and the Establishment of the Outer/Inner Configuration of Polar/Apolar Cells4. Activation of Lineage-Specific Genetic Programs in the Outer/Inner Cells to Form the TE and ICM Lineages; 5. How Do the Cells Within the Embryo Sense Their Position to Properly Regulate Hippo Signaling?; 6. Future Perspectives; Acknowledgments; References; Further Reading; Chapter Three: Cell Fate Decisions During Preimplantation Mammalian Development; 1. Introduction; 2. Gene Knockouts Pave the Way to Understand Cell Fate Decisions; 3. Different Patterns of TF Expression Levels
4. Gene Expression Dynamics5. TF Intracellular Transport Dynamics; 6. TF Nuclear-Cytoplasmic Shuttling in Embryos; 7. Cell-to-Cell Variability in the Early Embryo; 8. TF-DNA Binding Dynamics in the Embryo; 9. Epigenetic Regulation; 10. Additional Levels of Gene Regulation; 11. How Gene Regulation Impacts on Cell Shape and Position; Acknowledgments; References; Chapter Four: Our First Choice: Cellular and Genetic Underpinnings of Trophectoderm Identity and Differentiation in the M ... ; 1. Heterogeneity Emergence in the Mouse Embryo; 2. The TE Gene Regulatory Network
3. Establishment of TE Fate4. Plasticity During Lineage Segregation; 5. Recapitulating TE Identity in Culture; 6. TE Derivatives and Their Role in the Postimplantation Embryo; 7. Conclusions; Acknowledgments; References; Chapter Five: Primitive Endoderm Differentiation: From Specification to Epithelialization; 1. Introduction; 2. Generation of Trophectoderm and Inner Cell Mass Cell Lineages; 3. Regulation of the Epi/PrE Specification; 4. Mechanism for Salt and Pepper Pattern Propagation; 5. Induction of Epi/PrE Specification; 6. PrE Maturation Through the FGF Pathway
7. Other Signaling Pathways Involved in PrE Maturation and Maintenance8. Cell Sorting and PrE Epithelialization at the Late Blastocyst Stage; 9. The PrE Derivatives: The Visceral and the Parietal Endoderm; 10. Conclusion; References; Chapter Six: The Regulative Nature of Mammalian Embryos; 1. Introduction; 2. Blastomere Potency to Give Rise to the Whole Organism; 2.1. Compensation for the Loss: Embryo Splitting as a Proof of Totipotency and Plasticity of Blastomeres; 2.2. Monozygotic Multiplets: Proof of Totipotency of Blastomeres in Nature