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Stem cell proliferation and differentiation

Title
Stem cell proliferation and differentiation [electronic resource] / edited by Thomas G. Fazzio.
ISBN
9780128128916
0128128917
9780128128909
0128128909
Published
Cambridge, MA : Academic Press, 2020.
Physical Description
1 online resource
Local Notes
Access is available to the Yale community.
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Access restricted by licensing agreement.
Variant and related titles
Elsevier ScienceDirect All Books. OCLC KB.
Other formats
Print version:
Format
Books / Online
Language
English
Added to Catalog
September 08, 2020
Series
Current topics in developmental biology ; 138.
Current Topics in Developmental Biology ; 138
Contents
Intro
Stem Cell Proliferation and Differentiation
Copyright
Contents
Contributors
Preface
1. Chromatin regulation and dynamics
2. Long noncoding RNAs and RNA-binding proteins
3. Distinct modes of pluripotency
4. Differentiation of pluripotent stem cells
5. Metabolic control of cell state
6. Conclusions and perspectives
Chapter One: Chromatin regulation and dynamics in stem cells
1. Chromatin compaction, structure, and function
1.1. Nucleosomes are formed from DNA interacting with an octamer of four histone proteins
1.2. Chromatin structure balances DNA compaction and accessibility
2. Chromatin dynamics regulate gene expression
3. ATP-dependent nucleosome remodeling complexes establish and maintain chromatin state
3.1. SWI/SNF family nucleosome remodeling factors
3.2. INO80 family nucleosome remodeling factors
3.3. ISWI family nucleosome remodeling factors
3.4. CHD family nucleosome remodeling factors
3.5. Summary
4. Histone modifications provide an additional layer of gene regulation
4.1. Histone acetylation and deacetylation
4.2. Histone methylation and demethylation
4.3. Polycomb group proteins mediate H3K27me3 and silencing of developmental genes
5. Histone chaperones and histone variants regulate chromatin structure
6. Histone H2A variants
6.1. H2A.Z is a histone variant associated with active transcription
6.2. H2A.X is a marker of DNA double-strand breaks
6.3. macroH2A is associated with repression and heterochromatin
7. Histone H3 variants
7.1. H3.3 marks regulatory, repetitive, and actively transcribed regions
7.2. CENP-A is a centromere-specific variant of histone H3
8. Histone chaperones
8.1. FACT facilitates H2A/H2B dimer exchange to promote nucleosome-templated activities
8.2. CAF1 and ASF1 promote incorporation of H3 and H4 onto newly synthesized DNA
8.3. HIRA deposits H3.3 at actively transcribed and regulatory regions of chromatin
8.4. ATRX/DAXX deposit H3.3 at telomeres and pericentric heterochromatin
8.5. The NAP1 family import newly translated histones from the cytoplasm to the nucleus
8.6. INO80 family members possess both nucleosome remodeling and histone chaperone activities
9. Chromatin structure is dynamic and highly regulated
10. Stem cell chromatin is dynamic and tuned to regulate cell fate
11. ES cells carefully regulate their chromatin via specialized transcription factors
11.1. Master regulators of pluripotency
11.2. Pioneer transcription factors
12. Embryonic stem cell chromatin is poised for action
13. Histone modifications are specifically regulated in stem cells to maintain pluripotency and facilitate differentiation
13.1. H3K56ac regulates pluripotency factors and developmental regulators
13.2. Bivalent promoters mark lowly expressed but poised genes in ES cells
Subjects (Medical)
Stem Cells.
Cell Proliferation.
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