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Effects of peri-adolescent licit and illicit drug use on the developing CNS. Part I
Title
Effects of peri-adolescent licit and illicit drug use on the developing CNS. Part I [electronic resource] / Edited by Richard L. Bell, Shafiqur Rahman.
ISBN
9780128208069
0128208066
9780128208052
0128208058
Published
Cambridge, MA : Academic Press, 2021.
Physical Description
1 online resource.
Local Notes
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Variant and related titles
Elsevier ScienceDirect All Books. OCLC KB.
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ebook version :
Original
Print version: EFFECTS OF PERI-ADOLESCENT LICIT AND ILLICIT DRUG USE ON THE DEVELOPING CNS. [S.l.] : ELSEVIER ACADEMIC PRESS, 2021
Format
Books / Online
Language
English
Added to Catalog
January 07, 2022
Series
International review of neurobiology ; volume 160
Contents
Intro
Effects of Peri-Adolescent Licit and Illicit Drug Use on the Developing CNS Part I
Copyright
Contents
Contributors
Preface
Peri-adolescent addiction as a public health issue
Neurodevelopment during adolescence and emerging adulthood
Adolescent timing in rodents
The addiction cycle
Learning and memory
Chapters in Part I of the special issue
References
Chapter One: The persistent impact of adolescent binge alcohol on adult brain structural, cellular, and behavioral pathol ...
1. Introduction
1.1. Alcohol use in human adolescents increases risk for developing an alcohol use disorder in adulthood
1.2. Adolescent intermittent ethanol (AIE) exposure increases adult drinking
2. Brain maturation during adolescence creates a window of vulnerability for injury
2.1. Adolescent maturation of neurocircuitry
2.2. Adolescent maturation of brain glia
3. Persistent changes in adult brain after adolescent binge alcohol
3.1. Long-lasting changes in MRI-assessed structure
3.2. Cellular changes in brain after adolescent binge drinking
3.3. Loss of adult neurogenesis
3.4. Lasting changes in adult brain gene expression
3.5. Adolescent alcohol exposure-induced changes in adult behavior
4. Neuroimmune signaling and epigenetic mechanisms
4.1. Microglial memory
4.2. Microglia, intoxication, and priming during withdrawal
4.3. Neuronal and glial neuroimmune signaling
4.4. Immune signaling and histone modifications with transcriptional silencers and enhancers
4.5. Epigenetic cholinergic neuronal phenotype loss and trophic-proinflammatory balance
5. Reversibility of persistent adolescent alcohol pathology: Exercise, anti-inflammatories, and promotion of cholinergic ...
6. Adolescent alcohol abuse as a possible risk factor for cognitive decline with aging
7. Conclusion
References
Chapter Two: Neuroepigenetic consequences of adolescent ethanol exposure
1. Introduction
2. Epigenetic modifications
3. Ethanolś metabolic influence on epigenetics
4. Ethanol-induced epigenetic alterations in the amygdala
5. Ethanol-induced epigenetic alterations in the prefrontal cortex
6. Ethanol-induced epigenetic alterations in the hippocampus
7. Conclusion and future directions
Acknowledgments
References
Chapter Three: Trajectories of brain development reveal times of risk and factors promoting resilience to alcohol use dur ...
1. Epidemiology of alcohol use in adolescence
2. Overview of factors associated with alcohol misuse in adolescence
3. Alcohol use during adolescence: Its effect on brain structure and function
3.1. Brain structural disturbance
3.2. Brain functional impairments
3.3. Short conclusion
4. Resilience and brain mechanisms
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