Discovery of Small-Molecule Modulators of Protein-RNA Interactions for Treating Cancer and COVID-19 [electronic resource] / by Wan Gi Byun.

9789811978142

1st ed. 2023.

Singapore : Springer Nature Singapore : Imprint: Springer, 2023.

1 online resource (XXXII, 128 p.) 142 illus., 57 illus. in color.

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This book describes the development of novel protein-RNA-binding assays and their applications in a high-throughput manner for the identification of small-molecule modulators of protein-RNA interactions to treat cancer and COVID-19. Modulating protein-RNA interactions with small molecules is expected to provide novel biological insights of the interrelation of diseases with the protein-RNA interactome. The modulations may also be exploited therapeutically. For these reasons, the development of a simple, reliable, and sensitive protein-RNA-binding assay is necessary for high-throughput screening to discover new effective chemical entities capable of acting on diverse protein-RNA interactions. This book discusses the discovery of small-molecule modulators targeting protein-RNA interactions that are potentially valuable to treat cancer and COVID-19 by constructing novel high-throughput screening methods. The results of this dissertation provide valuable insights into the regulation of protein-RNA interactions in chemical biology and drug development.

Springer ENIN.

Books / Online

English

February 22, 2023

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