Polyamine drug discovery [electronic resource] / edited by Patrick M. Woster, Robert A. Casero Jr.

[Cambridge, U.K.] : Royal Society of Chemistry, [2011], ©2012.

1 online resource (xii, 289 pages) : illustrations.

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Polyamines are ubiquitous molecules that are involved in a number of important cellular processes. Aberrations in their function or metabolism play a role in diseases such as cancer and parasitic infection. A number of validated drug targets have been identified, including enzymes in the polyamine biosynthetic and catabolic pathways and the S-adenosylmethionine synthetic and salvage pathways. Polyamine Drug Discovery is the first comprehensive volume to cover all aspects of the design and development of potential therapeutics targeting polyamine metabolism. The book details research progress from 1975 to the present date and discusses the design and use of polyamine metabolism inhibitors as therapeutic agents. Various polyamine-containing drugs are described that can be used in chemotherapy, and as treatments for infections including trypanosomiasis, leishmaniasis and malaria. Finally, the roles of polyamine analogues in chemoprevention, polyamine-containing vectors for gene delivery, and the design of polyamine-based epigenetic modulators are detailed. Each chapter addresses a different aspect of polyamine drug discovery and all are written by medicinal and biological chemists with particular expertise in developing agents that modulate polyamine metabolism or function. The book will increase the visibility of polyamine drug discovery among pharmaceutical researchers and provide a valuable reference for everyone working in the field.

Royal society of chemistry 2011. OCLC KB.

Print version: Polyamine drug discovery. Cambridge : RSC Pub., ©2012

Books / Online

English

January 30, 2024

Includes bibliographical references and index.

Polyamine Drug DiscoveryOFC_Publicity; i-iv; v-vi; vii-xii; 1-27.pdf; 28-49; 50-77; 78-103; 104-134; 135-161; 162-190; 191-204; 205-237; 238-256; 257-276; 277-290.