Distributed in print by Oxford University Press.

"Developed from symposia sponsored by the Division of Fluorine Chemistry and the Division of Medicinal Chemistry."

Symposia held at the 210th annual meeting of the American Chemical Society and the 4th International Chemical Congress of Pacific Basin Societies.

Description based on publisher-supplied information and home-page.

Original

Online version

Original

ACS symposium series, 639

Recent Advances in the Biomedicinal Chemistry of Fluorine-Containing Compounds / Kirk, Kenneth L., Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 8A, Room B1A-02, Bethesda, MD 20892; Filler, Robert, Department of Biological, Chemical, and Physical Sciences, Illinois Institute of Technology, Chicago, IL 60616-3793 / http://dx.doi.org/10.1021/bk-1996-0639.ch001

Practical Synthesis of Enantiopure Fluoroamino Acids of Biological Interest by Asymmetric Aldol Reactions / Soloshonok, V. A., Current address: National Industrial Research Institute of Nagoya, Hirate-cho 1-1, Kita-ku, Nagoya City, Aichi 462, Japan / http://dx.doi.org/10.1021/bk-1996-0639.ch002

Synthesis and Incorporation of α-Trifluoromethyl-Substituted Amino Acids into Peptides / Koksch, Beate, Department of Biochemistry, University of Leipzig, Talstrasse 33, D-04103 Leipzig, Germany; Sewald, Norbert, Department of Organic Chemistry, University of Leipzig, Talstrasse 35, D-04103 Leipzig, Germany; Jakubke, Hans-Dieter, Department of Biochemistry, University of Leipzig, Talstrasse 33, D-04103 Leipzig, Germany; Burger, Klaus, Department of Organic Chemistry, University of Leipzig, Talstrasse 35, D-04103 Leipzig, Germany / http://dx.doi.org/10.1021/bk-1996-0639.ch003

Trifluoromethylated Amino Alcohols: New Synthetic Approaches and Medicinal Targets / Bégué, Jean-Pierre; Bonnet-Delpon, Danièle / http://dx.doi.org/10.1021/bk-1996-0639.ch004

Asymmetric Synthesis of Functionalized Fluorinated Cyclopropanes and Its Application to Fluoromethano Amino Acids / Taguchi, Takeo; Shibuya, Akira; Morikawa, Tsutomu / http://dx.doi.org/10.1021/bk-1996-0639.ch005

Synthesis and Properties of Novel Fluoroprostacyclins: Potent and Stable Prostacyclin Agonists / Matsumura, Yasushi; Nakano, Takashi; Asai, Tomoyuki; Morizawa, Yoshitomi / http://dx.doi.org/10.1021/bk-1996-0639.ch006

Preparation of Fluorinated Amino Acids with Tyrosine Phenol Lyase: Effects of Fluorination on Reaction Kinetics and Mechanism of Tyrosine Phenol Lyase and Tyrosine Protein Kinase Csk / VonTersch, R. L., Department of Chemistry, U.S. Naval Academy, Annapolis, MD 21402; Secundo, F., Instituto di Chimica degli Ormoni, CNR, via Mario Bianco 9, 20131 Milan, Italy; Phillips, R. S., Department of Chemistry, University of Georgia, Athens, GA 30602-2556, Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602-2556; Newton, M. G., Department of Chemistry, University of Georgia, Athens, GA 30602-2556 / http://dx.doi.org/10.1021/bk-1996-0639.ch007

Efficient Synthetic Routes to Chiral 6-Deoxy-6,6,6-trifluorosugars via Intramolecular 1,2-O,O-Silyl Migration / Yamazaki, Takashi; Mizutani, Kenji; Kitazume, Tomoya / http://dx.doi.org/10.1021/bk-1996-0639.ch008

Fluoroamino Acid Containing Analogues of Folic Acid and Methotrexate / Tsukamoto, Takashi, Departments of Chemistry and Medicinal Chemistry, University of Michigan, Ann Arbor, MI 48109-1055; Coward, James K., Departments of Chemistry and Medicinal Chemistry, University of Michigan, Ann Arbor, MI 48109-1055; McGuire, John J., Department of Experimental Therapeutics, Grace Cancer Drug Center, Roswell Park Cancer Institute, Buffalo, NY 14263 / http://dx.doi.org/10.1021/bk-1996-0639.ch009

Fluoro-olefin Isosteres as Peptidomimetics / Welch, J. T.; Lin, J.; Boros, L. G., Current address: Albany Molecular Research, 21 Corporate Circle, Albany, NY 12203; DeCorte, B., Current address: Janssen Research Foundation, Welsh and McKean Roads, Spring House, PA 19477; Bergmann, K., Current address: Syracuse Research Corporation, 1745 Jefferson Davis Highway, Suite 504, Arlington, VA 22202; Gimi, R., Current address: Brookhaven National Laboratory, Upton, NY 11973 / http://dx.doi.org/10.1021/bk-1996-0639.ch010

Molecular Design of Fluorine-Containing Peptide Mimetics / Cieplak, Piotr, Quantum Chemistry Laboratory, Department of Chemistry, University of Warsaw, Pasteura 1, Warsaw 02-093, Poland; Kollman, Peter A., Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143; Radomski, Jan P., Interdisciplinary Center for Modeling, University of Warsaw, Banacha 2, Warsaw 02-097, Poland / http://dx.doi.org/10.1021/bk-1996-0639.ch011

Mechanistic Studies of the Prenyl Transfer Reaction with Fluorinated Substrate Analogs / Poulter, C. Dale / http://dx.doi.org/10.1021/bk-1996-0639.ch012

Elucidation of the Mechanism of Inhibition of Human Immunodeficiency Virus 1 Protease by Difluorostatones / Schirlin, D., Strasbourg Center, Marion Merrell Dow Research Institute, 16 rue d'Ankara, 67080 Strasbourg Cedex, France; Rondeau, J. M., Strasbourg Center, Marion Merrell Dow Research Institute, 16 rue d'Ankara, 67080 Strasbourg Cedex, France; Podlogar, B., R. W. Johnson Pharmaceutical Research Institute, Route 202, P.O. Box 300, Raritan, NJ 08869; Tardif, C., Strasbourg Center, Marion Merrell Dow Research Institute, 16 rue d'Ankara, 67080 Strasbourg Cedex, France; Tarnus, C., Strasbourg Center, Marion Merrell Dow Research Institute, 16 rue d'Ankara, 67080 Strasbourg Cedex, France; Van Dorsselaer, V., Strasbourg Center, Marion Merrell Dow Research Institute, 16 rue d'Ankara, 67080 Strasbourg Cedex, France; Farr, R., Cincinnati Center, Marion Merrell Dow Research Institute, 2110 East Galbraith Road, Cincinnati, OH 45200 / http://dx.doi.org/10.1021/bk-1996-0639.ch013

Fluorine-Containing Peptidomimetics as Inhibitors of Aspartyl Proteases / Sham, Hing L. / http://dx.doi.org/10.1021/bk-1996-0639.ch014

Inhibition of Ornithine Aminotransferase: A New Target for Therapeutic Intervention / Ducep, J. B., Strasbourg Center, Marion Merrell Dow Research Institute, 16 rue d'Ankara, 67080 Strasbourg Cedex, France; Jund, K., Strasbourg Center, Marion Merrell Dow Research Institute, 16 rue d'Ankara, 67080 Strasbourg Cedex, France; Lesur, B., Strasbourg Center, Marion Merrell Dow Research Institute, 16 rue d'Ankara, 67080 Strasbourg Cedex, France; Sarhan, S., Strasbourg Center, Marion Merrell Dow Research Institute, 16 rue d'Ankara, 67080 Strasbourg Cedex, France; Schleimer, M., Strasbourg Center, Marion Merrell Dow Research Institute, 16 rue d'Ankara, 67080 Strasbourg Cedex, France; Zimmermann, P. R., Strasbourg Center, Marion Merrell Dow Research Institute, 16 rue d'Ankara, 67080 Strasbourg Cedex, France; Seiler, N., Groupe de Recherche en Thérapeutique Anticancéreuse, Unité de Recherche Associé au Centre National de la Recherche Scientifique 1529, Institut de Recherche Contre le Cancer, Faculté de Médecine, Université de Rennes, 2 avenue du Pr. Léon Bernard, F-35043 Rennes Cedex, France / http://dx.doi.org/10.1021/bk-1996-0639.ch015

Fluorinated Vitamin D3 Analog with In Vivo Anticancer Activity / Iseki, Katsuhiko; Kobayashi, Yoshiro / http://dx.doi.org/10.1021/bk-1996-0639.ch016

Syntheses, Biological Activity, and Conformational Analysis of Fluorine-Containing Taxoids / Ojima, Iwao, Department of Chemistry, State University of New York at Stony Brook, Stony Brook, NY 11794-3400; Kuduk, Scott D., Department of Chemistry, State University of New York at Stony Brook, Stony Brook, NY 11794-3400; Slater, John C., Department of Chemistry, State University of New York at Stony Brook, Stony Brook, NY 11794-3400; Gimi, Rayomand H., Department of Chemistry, State University of New York at Stony Brook, Stony Brook, NY 11794-3400; Sun, Chung Ming, Department of Chemistry, State University of New York at Stony Brook, Stony Brook, NY 11794-3400; Chakravarty, Subrata, Department of Chemistry, State University of New York at Stony Brook, Stony Brook, NY 11794-3400; Ourevitch, Michele, Faculté de Pharmacie, BIOCIS-Centre National de la Recherche Scientifique, Université Paris-Sud, 5 rue Jean-Baptiste Clément, 92296 Châtenay-Malabry, France; Abouabdellah, Ahmed, Faculté de Pharmacie, BIOCIS-Centre National de la Recherche Scientifique, Université Paris-Sud, 5 rue Jean-Baptiste Clément, 92296 Châtenay-Malabry, France; Bonnet-Delpon, Danièle, Faculté de Pharmacie, BIOCIS-Centre National de la Recherche Scientifique, Université Paris-Sud, 5 rue Jean-Baptiste Clément, 92296 Châtenay-Malabry, France; Bégué, Jean-Pierre, Faculté de Pharmacie, BIOCIS-Centre National de la Recherche Scientifique, Université Paris-Sud, 5 rue Jean-Baptiste Clément, 92296 Châtenay-Malabry, France; Veith, Jean M., Department of Experimental Therapeutics, Grace Cancer Drug Center, Roswell Park Cancer Institute, Buffalo, NY 14263; Pera, Paula, Department of Experimental Therapeutics, Grace Cancer Drug Center, Roswell Park Cancer Institute, Buffalo, NY 14263; Bernacki, Ralph J., Department of Experimental Therapeutics, Grace Cancer Drug Center, Roswell Park Cancer Institute, Buffalo, NY 14263 / http://dx.doi.org/10.1021/bk-1996-0639.ch017

Design of a Fluoro-olefin Cytidine Nucleoside as a Bioprecursor of a Mechanism-Based Inhibitor of Ribonucleotide Reductase / McCarthy, James R., Hoechst Marion Roussel, Inc., 2110 East Galbraith Road, Cincinnati, OH 45215, Current address: Department of Medicinal Chemistry, Neurocrine Biosciences, Inc., 3050 Science Park Road, San Diego, CA 92121-1102; Sunkara, Prasad S., Hoechst Marion Roussel, Inc., 2110 East Galbraith Road, Cincinnati, OH 45215, Current address: Department of Medicinal Chemistry, Neurocrine Biosciences, Inc., 3050 Science Park Road, San Diego, CA 92121-1102; Matthews, Donald P., Hoechst Marion Roussel, Inc., 2110 East Galbraith Road, Cincinnati, OH 45215, Current address: Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285; Bitonti, Alan J., Hoechst Marion Roussel, Inc., 2110 East Galbraith Road, Cincinnati, OH 45215; Jarvi, Esa T., Hoechst Marion Roussel, Inc., 2110 East Galbraith Road, Cincinnati, OH 45215; Sabol, Jeffrey S., Hoechst Marion Roussel, Inc., 2110 East Galbraith Road, Cincinnati, OH 45215; Resvick, Robert J., Hoechst Marion Roussel, Inc., 2110 East Galbraith Road, Cincinnati, OH 45215; Huber, Edward W., Hoechst Marion Roussel, Inc., 2110 East Galbraith Road, Cincinnati, OH 45215; van der Donk, Wilfred A., Departments of Chemistry and Biology, Massachusetts Institute of Technology, Cambridge, MA 02139; Yu, Guixue, Departments of Chemistry and Biology, Massachusetts Institute of Technology, Cambridge, MA 02139; Stubbe, JoAnne, Departments of Chemistry and Biology, Massachusetts Institute of Technology, Cambridge, MA 02139 / http://dx.doi.org/10.1021/bk-1996-0639.ch018

Synthesis and Biological Activity of 2',2'-Difluorodeoxycytidine (Gemcitabine) / Hertel, L. W., Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285; Kroin, J. S., Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285; Grossman, C. S., Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285; Grindey, Gerald B., Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285; Dorr, A. F., Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285; Storniolo, A. M. V., Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285; Plunkett, W., Department of Medical Oncology, M. D. Anderson Cancer Center, University of Texas, Houston, TX 77030; Gandhi, V., Department of Medical Oncology, M. D. Anderson Cancer Center, University of Texas, Houston, TX 77030; Huang, P., Department of Medical Oncology, M. D. Anderson Cancer Center, University of Texas, Houston, TX 77030 / http://dx.doi.org/10.1021/bk-1996-0639.ch019

Fluorinated Sugars as Probes of Glycosidase Mechanisms / Namchuk, Mark; Braun, Curtis; McCarter, John D.; Withers, Stephen G. / http://dx.doi.org/10.1021/bk-1996-0639.ch020

19F-Labeled Amino Acids as Structural and Dynamic Probes in Membrane-Associated Proteins / Sun, Zhen-Yu; Pratt, E. Ann; Ho, Chien / http://dx.doi.org/10.1021/bk-1996-0639.ch021

Fluorinated Amino Acids in Nerve Systems / Kirk, Kenneth L.; Nie, Jun-Ying / http://dx.doi.org/10.1021/bk-1996-0639.ch022

18F-Labeled Tracers for Positron Emission Tomography Studies in the Neurosciences / Ding, Yu-Shin; Fowler, Joanna S. / http://dx.doi.org/10.1021/bk-1996-0639.ch023

Organofluorine compounds > Physiological effect.

Organofluorine compounds > Synthesis.

Organofluorine compounds > Therapeutic use.

Amino acids > Synthesis > Methodology.

Amino alcohols > Synthesis.

Prostacyclin > Synthesis.

Lyases > Mechamism of action.

Methotrexate > Synthesis.

Folic acid > Synthesis.

HIV (Viruses) > Inhibitors.

Proteolytic enzymes > Inhibitors.

Aminotransferases > Inhibitors.

Enantiomers > Inhibitors.

Diterpenes > Synthesis.

Fluorocarbohydrates > Analysis.

Nuclear magnetic resonance spectroscopy > Application.

Tomography, Emission > Application.

Fluorine - pharmacology.

Fluorine - therapeutic use.

Chemistry, Organic.

Chemistry, Pharmaceutical.

Amino Acids - chemical synthesis.

Amino Alcohols - chemical synthesis.

Epoprostenol - chemical synthesis.

Lyases - pharmacology.

Methotrexate - chemical synthesis.

Folic Acid - chemical synthesis.

HIV Protease Inhibitors.

Peptide Hydrolases.

Aminotransferases - antagonists & inhibitors.

Diterpenes - chemical synthesis.

Magnetic Resonance Spectroscopy.

Tomography.