Recent Advances in the Biomedicinal Chemistry of Fluorine-Containing Compounds / Kirk, Kenneth L., Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 8A, Room B1A-02, Bethesda, MD 20892; Filler, Robert, Department of Biological, Chemical, and Physical Sciences, Illinois Institute of Technology, Chicago, IL 60616-3793 / http://dx.doi.org/10.1021/bk-1996-0639.ch001
Practical Synthesis of Enantiopure Fluoroamino Acids of Biological Interest by Asymmetric Aldol Reactions / Soloshonok, V. A., Current address: National Industrial Research Institute of Nagoya, Hirate-cho 1-1, Kita-ku, Nagoya City, Aichi 462, Japan / http://dx.doi.org/10.1021/bk-1996-0639.ch002
Synthesis and Incorporation of α-Trifluoromethyl-Substituted Amino Acids into Peptides / Koksch, Beate, Department of Biochemistry, University of Leipzig, Talstrasse 33, D-04103 Leipzig, Germany; Sewald, Norbert, Department of Organic Chemistry, University of Leipzig, Talstrasse 35, D-04103 Leipzig, Germany; Jakubke, Hans-Dieter, Department of Biochemistry, University of Leipzig, Talstrasse 33, D-04103 Leipzig, Germany; Burger, Klaus, Department of Organic Chemistry, University of Leipzig, Talstrasse 35, D-04103 Leipzig, Germany / http://dx.doi.org/10.1021/bk-1996-0639.ch003
Trifluoromethylated Amino Alcohols: New Synthetic Approaches and Medicinal Targets / Bégué, Jean-Pierre; Bonnet-Delpon, Danièle / http://dx.doi.org/10.1021/bk-1996-0639.ch004
Asymmetric Synthesis of Functionalized Fluorinated Cyclopropanes and Its Application to Fluoromethano Amino Acids / Taguchi, Takeo; Shibuya, Akira; Morikawa, Tsutomu / http://dx.doi.org/10.1021/bk-1996-0639.ch005
Synthesis and Properties of Novel Fluoroprostacyclins: Potent and Stable Prostacyclin Agonists / Matsumura, Yasushi; Nakano, Takashi; Asai, Tomoyuki; Morizawa, Yoshitomi / http://dx.doi.org/10.1021/bk-1996-0639.ch006
Preparation of Fluorinated Amino Acids with Tyrosine Phenol Lyase: Effects of Fluorination on Reaction Kinetics and Mechanism of Tyrosine Phenol Lyase and Tyrosine Protein Kinase Csk / VonTersch, R. L., Department of Chemistry, U.S. Naval Academy, Annapolis, MD 21402; Secundo, F., Instituto di Chimica degli Ormoni, CNR, via Mario Bianco 9, 20131 Milan, Italy; Phillips, R. S., Department of Chemistry, University of Georgia, Athens, GA 30602-2556, Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602-2556; Newton, M. G., Department of Chemistry, University of Georgia, Athens, GA 30602-2556 / http://dx.doi.org/10.1021/bk-1996-0639.ch007
Efficient Synthetic Routes to Chiral 6-Deoxy-6,6,6-trifluorosugars via Intramolecular 1,2-O,O-Silyl Migration / Yamazaki, Takashi; Mizutani, Kenji; Kitazume, Tomoya / http://dx.doi.org/10.1021/bk-1996-0639.ch008
Fluoroamino Acid Containing Analogues of Folic Acid and Methotrexate / Tsukamoto, Takashi, Departments of Chemistry and Medicinal Chemistry, University of Michigan, Ann Arbor, MI 48109-1055; Coward, James K., Departments of Chemistry and Medicinal Chemistry, University of Michigan, Ann Arbor, MI 48109-1055; McGuire, John J., Department of Experimental Therapeutics, Grace Cancer Drug Center, Roswell Park Cancer Institute, Buffalo, NY 14263 / http://dx.doi.org/10.1021/bk-1996-0639.ch009
Fluoro-olefin Isosteres as Peptidomimetics / Welch, J. T.; Lin, J.; Boros, L. G., Current address: Albany Molecular Research, 21 Corporate Circle, Albany, NY 12203; DeCorte, B., Current address: Janssen Research Foundation, Welsh and McKean Roads, Spring House, PA 19477; Bergmann, K., Current address: Syracuse Research Corporation, 1745 Jefferson Davis Highway, Suite 504, Arlington, VA 22202; Gimi, R., Current address: Brookhaven National Laboratory, Upton, NY 11973 / http://dx.doi.org/10.1021/bk-1996-0639.ch010
Molecular Design of Fluorine-Containing Peptide Mimetics / Cieplak, Piotr, Quantum Chemistry Laboratory, Department of Chemistry, University of Warsaw, Pasteura 1, Warsaw 02-093, Poland; Kollman, Peter A., Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143; Radomski, Jan P., Interdisciplinary Center for Modeling, University of Warsaw, Banacha 2, Warsaw 02-097, Poland / http://dx.doi.org/10.1021/bk-1996-0639.ch011
Mechanistic Studies of the Prenyl Transfer Reaction with Fluorinated Substrate Analogs / Poulter, C. Dale / http://dx.doi.org/10.1021/bk-1996-0639.ch012
Elucidation of the Mechanism of Inhibition of Human Immunodeficiency Virus 1 Protease by Difluorostatones / Schirlin, D., Strasbourg Center, Marion Merrell Dow Research Institute, 16 rue d'Ankara, 67080 Strasbourg Cedex, France; Rondeau, J. M., Strasbourg Center, Marion Merrell Dow Research Institute, 16 rue d'Ankara, 67080 Strasbourg Cedex, France; Podlogar, B., R. W. Johnson Pharmaceutical Research Institute, Route 202, P.O. Box 300, Raritan, NJ 08869; Tardif, C., Strasbourg Center, Marion Merrell Dow Research Institute, 16 rue d'Ankara, 67080 Strasbourg Cedex, France; Tarnus, C., Strasbourg Center, Marion Merrell Dow Research Institute, 16 rue d'Ankara, 67080 Strasbourg Cedex, France; Van Dorsselaer, V., Strasbourg Center, Marion Merrell Dow Research Institute, 16 rue d'Ankara, 67080 Strasbourg Cedex, France; Farr, R., Cincinnati Center, Marion Merrell Dow Research Institute, 2110 East Galbraith Road, Cincinnati, OH 45200 / http://dx.doi.org/10.1021/bk-1996-0639.ch013
Fluorine-Containing Peptidomimetics as Inhibitors of Aspartyl Proteases / Sham, Hing L. / http://dx.doi.org/10.1021/bk-1996-0639.ch014
Inhibition of Ornithine Aminotransferase: A New Target for Therapeutic Intervention / Ducep, J. B., Strasbourg Center, Marion Merrell Dow Research Institute, 16 rue d'Ankara, 67080 Strasbourg Cedex, France; Jund, K., Strasbourg Center, Marion Merrell Dow Research Institute, 16 rue d'Ankara, 67080 Strasbourg Cedex, France; Lesur, B., Strasbourg Center, Marion Merrell Dow Research Institute, 16 rue d'Ankara, 67080 Strasbourg Cedex, France; Sarhan, S., Strasbourg Center, Marion Merrell Dow Research Institute, 16 rue d'Ankara, 67080 Strasbourg Cedex, France; Schleimer, M., Strasbourg Center, Marion Merrell Dow Research Institute, 16 rue d'Ankara, 67080 Strasbourg Cedex, France; Zimmermann, P. R., Strasbourg Center, Marion Merrell Dow Research Institute, 16 rue d'Ankara, 67080 Strasbourg Cedex, France; Seiler, N., Groupe de Recherche en Thérapeutique Anticancéreuse, Unité de Recherche Associé au Centre National de la Recherche Scientifique 1529, Institut de Recherche Contre le Cancer, Faculté de Médecine, Université de Rennes, 2 avenue du Pr. Léon Bernard, F-35043 Rennes Cedex, France / http://dx.doi.org/10.1021/bk-1996-0639.ch015
Fluorinated Vitamin D3 Analog with In Vivo Anticancer Activity / Iseki, Katsuhiko; Kobayashi, Yoshiro / http://dx.doi.org/10.1021/bk-1996-0639.ch016
Syntheses, Biological Activity, and Conformational Analysis of Fluorine-Containing Taxoids / Ojima, Iwao, Department of Chemistry, State University of New York at Stony Brook, Stony Brook, NY 11794-3400; Kuduk, Scott D., Department of Chemistry, State University of New York at Stony Brook, Stony Brook, NY 11794-3400; Slater, John C., Department of Chemistry, State University of New York at Stony Brook, Stony Brook, NY 11794-3400; Gimi, Rayomand H., Department of Chemistry, State University of New York at Stony Brook, Stony Brook, NY 11794-3400; Sun, Chung Ming, Department of Chemistry, State University of New York at Stony Brook, Stony Brook, NY 11794-3400; Chakravarty, Subrata, Department of Chemistry, State University of New York at Stony Brook, Stony Brook, NY 11794-3400; Ourevitch, Michele, Faculté de Pharmacie, BIOCIS-Centre National de la Recherche Scientifique, Université Paris-Sud, 5 rue Jean-Baptiste Clément, 92296 Châtenay-Malabry, France; Abouabdellah, Ahmed, Faculté de Pharmacie, BIOCIS-Centre National de la Recherche Scientifique, Université Paris-Sud, 5 rue Jean-Baptiste Clément, 92296 Châtenay-Malabry, France; Bonnet-Delpon, Danièle, Faculté de Pharmacie, BIOCIS-Centre National de la Recherche Scientifique, Université Paris-Sud, 5 rue Jean-Baptiste Clément, 92296 Châtenay-Malabry, France; Bégué, Jean-Pierre, Faculté de Pharmacie, BIOCIS-Centre National de la Recherche Scientifique, Université Paris-Sud, 5 rue Jean-Baptiste Clément, 92296 Châtenay-Malabry, France; Veith, Jean M., Department of Experimental Therapeutics, Grace Cancer Drug Center, Roswell Park Cancer Institute, Buffalo, NY 14263; Pera, Paula, Department of Experimental Therapeutics, Grace Cancer Drug Center, Roswell Park Cancer Institute, Buffalo, NY 14263; Bernacki, Ralph J., Department of Experimental Therapeutics, Grace Cancer Drug Center, Roswell Park Cancer Institute, Buffalo, NY 14263 / http://dx.doi.org/10.1021/bk-1996-0639.ch017
Design of a Fluoro-olefin Cytidine Nucleoside as a Bioprecursor of a Mechanism-Based Inhibitor of Ribonucleotide Reductase / McCarthy, James R., Hoechst Marion Roussel, Inc., 2110 East Galbraith Road, Cincinnati, OH 45215, Current address: Department of Medicinal Chemistry, Neurocrine Biosciences, Inc., 3050 Science Park Road, San Diego, CA 92121-1102; Sunkara, Prasad S., Hoechst Marion Roussel, Inc., 2110 East Galbraith Road, Cincinnati, OH 45215, Current address: Department of Medicinal Chemistry, Neurocrine Biosciences, Inc., 3050 Science Park Road, San Diego, CA 92121-1102; Matthews, Donald P., Hoechst Marion Roussel, Inc., 2110 East Galbraith Road, Cincinnati, OH 45215, Current address: Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285; Bitonti, Alan J., Hoechst Marion Roussel, Inc., 2110 East Galbraith Road, Cincinnati, OH 45215; Jarvi, Esa T., Hoechst Marion Roussel, Inc., 2110 East Galbraith Road, Cincinnati, OH 45215; Sabol, Jeffrey S., Hoechst Marion Roussel, Inc., 2110 East Galbraith Road, Cincinnati, OH 45215; Resvick, Robert J., Hoechst Marion Roussel, Inc., 2110 East Galbraith Road, Cincinnati, OH 45215; Huber, Edward W., Hoechst Marion Roussel, Inc., 2110 East Galbraith Road, Cincinnati, OH 45215; van der Donk, Wilfred A., Departments of Chemistry and Biology, Massachusetts Institute of Technology, Cambridge, MA 02139; Yu, Guixue, Departments of Chemistry and Biology, Massachusetts Institute of Technology, Cambridge, MA 02139; Stubbe, JoAnne, Departments of Chemistry and Biology, Massachusetts Institute of Technology, Cambridge, MA 02139 / http://dx.doi.org/10.1021/bk-1996-0639.ch018
Synthesis and Biological Activity of 2',2'-Difluorodeoxycytidine (Gemcitabine) / Hertel, L. W., Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285; Kroin, J. S., Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285; Grossman, C. S., Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285; Grindey, Gerald B., Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285; Dorr, A. F., Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285; Storniolo, A. M. V., Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285; Plunkett, W., Department of Medical Oncology, M. D. Anderson Cancer Center, University of Texas, Houston, TX 77030; Gandhi, V., Department of Medical Oncology, M. D. Anderson Cancer Center, University of Texas, Houston, TX 77030; Huang, P., Department of Medical Oncology, M. D. Anderson Cancer Center, University of Texas, Houston, TX 77030 / http://dx.doi.org/10.1021/bk-1996-0639.ch019
Fluorinated Sugars as Probes of Glycosidase Mechanisms / Namchuk, Mark; Braun, Curtis; McCarter, John D.; Withers, Stephen G. / http://dx.doi.org/10.1021/bk-1996-0639.ch020
19F-Labeled Amino Acids as Structural and Dynamic Probes in Membrane-Associated Proteins / Sun, Zhen-Yu; Pratt, E. Ann; Ho, Chien / http://dx.doi.org/10.1021/bk-1996-0639.ch021
Fluorinated Amino Acids in Nerve Systems / Kirk, Kenneth L.; Nie, Jun-Ying / http://dx.doi.org/10.1021/bk-1996-0639.ch022
18F-Labeled Tracers for Positron Emission Tomography Studies in the Neurosciences / Ding, Yu-Shin; Fowler, Joanna S. / http://dx.doi.org/10.1021/bk-1996-0639.ch023