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ACS symposium series, 1115

Galectins in Disease and Potential Therapeutic Approaches / Klyosov, Anatole A.; Traber, Peter G. / http://dx.doi.org/10.1021/bk-2012-1115.ch001

Low-Molecular Weight Inhibitors of Galectins / Leffler, Hakon, Section MIG, Department of Laboratory Medicine, Lund University, Sölvegatan 23, SE-223 62, Lund, Sweden; Nilsson, Ulf J., Center for Analysis and Synthesis, Lund University, POB 124, SE-221 00 Lund, Sweden / http://dx.doi.org/10.1021/bk-2012-1115.ch002

From Carbohydrate to Peptidomimetic Inhibitors of Galectins / Mayo, Kevin H. / http://dx.doi.org/10.1021/bk-2012-1115.ch003

Intracellular Galectins: Platforms for Assembly of Macromolecular Complexes / Wang, John L., Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824; Haudek, Kevin C., Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824; Voss, Patricia G., Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824; Patterson, Ronald J., Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan 48824; Arnoys, Eric J., Department of Chemistry and Biochemistry, Calvin College, Grand Rapids, Michigan 49546 / http://dx.doi.org/10.1021/bk-2012-1115.ch004

Galectins as Novel Regulators of Platelet Signaling and Function: Therapeutic Implications / Rabinovich, Gabriel A., Laboratory of Immunopathology, Institute of Experimental Medicine (IMEX), and National Academy of Medicine, Argentina; Schattner, Mirta, Laboratory of Experimental Thrombosis, Institute of Biology and Experimental Medicine (IBYME), CONICET, National Academy of Medicine, Argentina / http://dx.doi.org/10.1021/bk-2012-1115.ch005

Galectin-1 Cross-Linking of GM1 Ganglioside in Autoimmune Suppression / Ledeen, Robert W., Department of Neurology and Neurosciences and New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07101; Wu, Gusheng, Department of Neurology and Neurosciences and New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07101; Bleich, David, Department of Medicine, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 17101; Lu, Zi-Hua, Department of Neurology and Neurosciences and New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07101; Gabius, Hans-Joachim, Institute of Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig-Maximilians-University Munich, Munich, Germany / http://dx.doi.org/10.1021/bk-2012-1115.ch006

How To Build "Lean and Mean" Anti-Tumor T Cells: A Strategic View into the Anti-Carbohydrate Action of Fluorinated Glucosamine Analogs / Dimitroff, Charles J. / http://dx.doi.org/10.1021/bk-2012-1115.ch007

Post-Translational Modification of Galectin-3 and Its Role in Biological Function / Byrd, James C.; Mazurek, Nachman; Bresalier, Robert S. / http://dx.doi.org/10.1021/bk-2012-1115.ch008

The Role of Galectin-3 in Malignant Melanoma / Radosavljevic, Gordana, Center for Molecular Medicine and Stem Cell Research, Faculty of Medicine Science, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia; Jovanovic, Ivan, Center for Molecular Medicine and Stem Cell Research, Faculty of Medicine Science, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia; Pantic, Jelena, Center for Molecular Medicine and Stem Cell Research, Faculty of Medicine Science, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia; Pejnovic, Nada, Center for Molecular Medicine and Stem Cell Research, Faculty of Medicine Science, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia; Arsenijevic, Nebojsa, Center for Molecular Medicine and Stem Cell Research, Faculty of Medicine Science, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia; Hsu, Daniel K., Department of Dermatology, School of Medicine, University of California Davis, Sacramento, California 95816, United States; Lukic, Miodrag L., Center for Molecular Medicine and Stem Cell Research, Faculty of Medicine Science, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia / http://dx.doi.org/10.1021/bk-2012-1115.ch009

Galectins as Novel Targets for the Treatment of Malignant Gliomas / Strik, Herwig M., Department of Neurology and Medical School, University of Marburg, Baldingerstrasse, D-35043 Marburg, Germany; Ocker, Matthias, Institute for Surgical Research, Medical School, University of Marburg, Baldingerstrasse, D-35043 Marburg, Germany / http://dx.doi.org/10.1021/bk-2012-1115.ch010

Dynamic Tuning of Galectins and Their Binding Sites During Mammary Tumor Progression and Metastasis / de Oliveira, Joana T.; Gärtner, Fátima / http://dx.doi.org/10.1021/bk-2012-1115.ch011

Galectin-3C: Human Lectin for Treatment of Cancer / Jarvis, Gary A., Center for Immunochemistry, Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, California 94121, Department of Laboratory Medicine, University of California, San Francisco, California 94143; Mirandola, Leonardo, Department of Internal Medicine at the Division of Hematology & Oncology, Texas Tech University Health Sciences Center and Southwest Cancer Treatment and Research Center, Lubbock, Texas 79415; Yuefei, Yu, Department of Internal Medicine at the Division of Hematology & Oncology, Texas Tech University Health Sciences Center and Southwest Cancer Treatment and Research Center, Lubbock, Texas 79415; Cobos, Everardo, Department of Internal Medicine at the Division of Hematology & Oncology, Texas Tech University Health Sciences Center and Southwest Cancer Treatment and Research Center, Lubbock, Texas 79415, Laura W. Bush Institute for Women's Health and Center for Women's Health and Gender-Based Medicine, Amarillo, Texas 79106; Chiriva-Internati, Maurizio, Department of Internal Medicine at the Division of Hematology & Oncology, Texas Tech University Health Sciences Center and Southwest Cancer Treatment and Research Center, Lubbock, Texas 79415, Laura W. Bush Institute for Women's Health and Center for Women's Health and Gender-Based Medicine, Amarillo, Texas 79106; John, Constance M., Center for Immunochemistry, Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, California 94121, MandalMed, 665 3rd Street, Suite 250, San Francisco, California 94107 / http://dx.doi.org/10.1021/bk-2012-1115.ch012

Angiostatic Cancer Therapy by Targeting Galectins in the Tumor Vasculature / Schulkens, Iris A., Angiogenesis Laboratory, Department of Radiation Oncology and Medical Oncology, and VU University Medical Center, De Boelelaan 1118, 1081 HV Amsterdam,The Netherlands; Griffioen, Arjan W., Angiogenesis Laboratory, Department of Radiation Oncology and Medical Oncology, and VU University Medical Center, De Boelelaan 1118, 1081 HV Amsterdam,The Netherlands; Thijssen, Victor L., Angiogenesis Laboratory, Department of Radiation Oncology and Medical Oncology, and VU University Medical Center, De Boelelaan 1118, 1081 HV Amsterdam,The Netherlands, Department of Radiation Oncology, VU University Medical Center, De Boelelaan 1118, 1081 HV Amsterdam, The Netherlands / http://dx.doi.org/10.1021/bk-2012-1115.ch013

Galectins and Pathologies: Role of Galectin-3 in the Communication between Leukemia Cells and the Microenvironment / Heisterkamp, Nora, Section of Molecular Carcinogenesis, Division of Hematology/Oncology and The Saban Research Institute of Children's Hospital, 4650 Sunset Boulevard, Los Angeles, California 90027, USA; Fei, Fei, Section of Molecular Carcinogenesis, Division of Hematology/Oncology and The Saban Research Institute of Children's Hospital, 4650 Sunset Boulevard, Los Angeles, California 90027, USA; Groffen, John, Departments of Pediatrics and Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA / http://dx.doi.org/10.1021/bk-2012-1115.ch014

Translational Rational for the Clinical Development of OTX-008: A Novel Drug That Inhibits Galectin-1 Expression in Human Cancer Models / Raymond, Eric; Astrorgue-Xerri, Lucile; Serova, Maria; Riveiro, Maria Eugenia; Faivre, Sandrine / http://dx.doi.org/10.1021/bk-2012-1115.ch015

Improving the Clinical Efficacy of Cancer Vaccines by Targeting Immune Suppression in Human Tumors / Demotte, Nathalie, Ludwig Institute for Cancer Research, WELBIO, and Université catholique de Louvain, de Duve Institute, 74 av. Hippocrate, P.O. Box B1-7403, B-1200 Brussels, Belgium; Antonopoulos, Aristotelis, Division of Molecular Biosciences, Imperial College London, South Kensington Campus, SW7 2AZ, United Kingdom; Baurain, Jean-François, Department of Oncology, Université catholique de Louvain, Cliniques Universitaires Saint-Luc, 10 av. Hippocrate, B-1200 Brussels, Belgium; Wieërs, Grégoire, Ludwig Institute for Cancer Research, WELBIO, and Université catholique de Louvain, de Duve Institute, 74 av. Hippocrate, P.O. Box B1-7403, B-1200 Brussels, Belgium, Current address: Department of Internal Medicine, Université catholique de Louvain, Cliniques Universitaires Saint-Luc, 10 av. Hippocrate, B-1200 Brussels, Belgium; Van Baren, Nicolas, Ludwig Institute for Cancer Research, WELBIO, and Université catholique de Louvain, de Duve Institute, 74 av. Hippocrate, P.O. Box B1-7403, B-1200 Brussels, Belgium; van der Bruggen, Pierre, Ludwig Institute for Cancer Research, WELBIO, and Université catholique de Louvain, de Duve Institute, 74 av. Hippocrate, P.O. Box B1-7403, B-1200 Brussels, Belgium / http://dx.doi.org/10.1021/bk-2012-1115.ch016

Targeting Galectin-3 Unveils the Complexity of Multiple Myeloma: A Sweet Context / Mirandola, Leonardo, Department of Health Sciences, Università degli Studi di Milano, Milano, Italy, Department of Internal Medicine, Pharmaceutical Sciences, Surgery, Obstetrics & Gynecology at the Division of Hematology & Oncology, School of Medicine, Texas Tech University, Health Sciences Center and Southwest Cancer Treatment and Research Center, 3601 4th St., Mail Stop 9410, Lubbock, Texas 79430, USA, Laura W. Bush Institute for Women's Health and Center for Women's Health and Gender-Based Medicine, Amarillo, Texas 79106, USA; Yu, Yuefei, Department of Internal Medicine, Pharmaceutical Sciences, Surgery, Obstetrics & Gynecology at the Division of Hematology & Oncology, School of Medicine, Texas Tech University, Health Sciences Center and Southwest Cancer Treatment and Research Center, 3601 4th St., Mail Stop 9410, Lubbock, Texas 79430, USA; John, Constance M., MandalMed, 665 3rd Street, Suite 250, San Francisco, California 94107, USA; Jenkins, Marjorie, Department of Internal Medicine, Pharmaceutical Sciences, Surgery, Obstetrics & Gynecology at the Division of Hematology & Oncology, School of Medicine, Texas Tech University, Health Sciences Center and Southwest Cancer Treatment and Research Center, 3601 4th St., Mail Stop 9410, Lubbock, Texas 79430, USA, Laura W. Bush Institute for Women's Health and Center for Women's Health and Gender-Based Medicine, Amarillo, Texas 79106, USA; Cobos, Everardo, Department of Internal Medicine, Pharmaceutical Sciences, Surgery, Obstetrics & Gynecology at the Division of Hematology & Oncology, School of Medicine, Texas Tech University, Health Sciences Center and Southwest Cancer Treatment and Research Center, 3601 4th St., Mail Stop 9410, Lubbock, Texas 79430, USA, Laura W. Bush Institute for Women's Health and Center for Women's Health and Gender-Based Medicine, Amarillo, Texas 79106, USA; Chiriva-Internati, Maurizio, Department of Internal Medicine, Pharmaceutical Sciences, Surgery, Obstetrics & Gynecology at the Division of Hematology & Oncology, School of Medicine, Texas Tech University, Health Sciences Center and Southwest Cancer Treatment and Research Center, 3601 4th St., Mail Stop 9410, Lubbock, Texas 79430, USA, Laura W. Bush Institute for Women's Health and Center for Women's Health and Gender-Based Medicine, Amarillo, Texas 79106, USA / http://dx.doi.org/10.1021/bk-2012-1115.ch017

Galectins in the Blood Circulation: Potential Therapeutic Targets of Cancer Metastasis / Duckworth, Carrie A.; Yu, Lu-Gang / http://dx.doi.org/10.1021/bk-2012-1115.ch018

A Therapeutic Role for Galectins in Acute Inflammation? / Cooper, Dianne / http://dx.doi.org/10.1021/bk-2012-1115.ch019

Galectins in Immune and Inflammatory Diseases: Insights from Experiments with Galectin Deficient Mice / Hsu, Daniel K., Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, Department of Dermatology, University of California-Davis, Sacramento, California; Yang, Ri-Yao, Department of Dermatology, University of California-Davis, Sacramento, California; Fermin, Agnes, Department of Dermatology, University of California-Davis, Sacramento, California; Liu, Fu-Tong, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, Department of Dermatology, University of California-Davis, Sacramento, California / http://dx.doi.org/10.1021/bk-2012-1115.ch020

Autoimmune Disorders in Galectin-3 Deficient Mice / Volarevic, Vladislav; Lukic, Miodrag L. / http://dx.doi.org/10.1021/bk-2012-1115.ch021

Galectin-3: A Central Regulator of Chronic Inflammation and Tissue Fibrosis / Henderson, Neil C., MRC Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, United Kingdom; Mackinnon, Alison C., MRC Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, United Kingdom; Rooney, Claire, Department of Respiratory Medicine and Allergy, King's College London, London, United Kingdom; Sethi, Tariq, Department of Respiratory Medicine and Allergy, King's College London, London, United Kingdom / http://dx.doi.org/10.1021/bk-2012-1115.ch022

The Role of Galectin-3 in Stellate Cell Activation and Liver Fibrosis / Jiang, Joy X., Department of Internal Medicine, Division of Gastroenterology and Hepatology, UC Davis Medical Center, 4635 2nd Avenue, Suite 1001, Sacramento, California 95817; Chen, Xiangling, Department of Internal Medicine, Division of Gastroenterology and Hepatology, UC Davis Medical Center, 4635 2nd Avenue, Suite 1001, Sacramento, California 95817; Fukada, Hiroo, Department of Internal Medicine, Division of Gastroenterology and Hepatology, UC Davis Medical Center, 4635 2nd Avenue, Suite 1001, Sacramento, California 95817; Hsu, Dan K., Department of Dermatology, UC Davis Medical Center, 4635 2nd Avenue, Suite 1001, Sacramento, California 95817; Liu, Fu-tong, Department of Dermatology, UC Davis Medical Center, 4635 2nd Avenue, Suite 1001, Sacramento, California 95817; Török, Natalie J., Department of Internal Medicine, Division of Gastroenterology and Hepatology, UC Davis Medical Center, 4635 2nd Avenue, Suite 1001, Sacramento, California 95817 / http://dx.doi.org/10.1021/bk-2012-1115.ch023

Galectin-3 Mediated Cardiovascular Fibrogenesis: An Important Cause of Heart Failure and Cardiovascular Mortality / Meijers, Wouter C.; de Boer, Rudolf A. / http://dx.doi.org/10.1021/bk-2012-1115.ch024

Mucins and Galectin-3 in Ocular Surface Health and Disease / Mauris, Jerome; Argüeso, Pablo / http://dx.doi.org/10.1021/bk-2012-1115.ch025

Role of Galectins in Wound Healing / Panjwani, Noorjahan / http://dx.doi.org/10.1021/bk-2012-1115.ch026

Editors' Biographies / http://dx.doi.org/10.1021/bk-2012-1115.ot001

Lectins > Therapeutic use.

Carrier proteins > Therapeutic use.

Lectins > Chemical inhibitors.

Macromolecules > Structure.

Platelet activating factor > Control.

Autoimmunity > Prevention.

Antineoplastic agents > Design.

Carbohydrates > Chemical inhibitors.

Lectins > Modification.

Melanoma > Analysis.

Gliomas > Treatment.

Protein binding > Health aspects.

Breast > Tumors > Analysis.

Cancer > Treatment.

Tumors > Blood-vessels > Chemical inhibitors.

Leukemia > Molecular aspects.

Cancer > Chemical inhibitors.

Cancer vaccines > Effectiveness > Technological innovations.

Metastasis > Prevention.

Inflammation > Chemical inhibitors.

Diseases > Chemical inhibitors.

Autoimmune diseases > Analysis.

Inflammation > Analysis.

Tissues > Fibrosis > Analysis.

Kupffer cells > Fibrosis > Analysis.

Liver > Fibrosis > Analysis.

Heart > Fibrosis > Analysis.

Eye > Diseases > Analysis.

Wound healing > Analysis.

Galectins - therapeutic use.

Molecular Targeted Therapy.

Galectins - antagonists & inhibitors.

Galectins - immunology.

Molecular Targeted Therapy - methods.

Carrier Proteins - therapeutic use.

Macromolecular Substances.

Platelet Activating Factor.

Autoimmunity.

Antineoplastic Agents.

Carbohydrates - antagonists & inhibitors.

Melanoma.

Glioma - therapy.

Protein Binding.

Breast Neoplasms.

Neoplasms - therapy.

Neoplasms, Vascular Tissue - drug therapy.

Leukemia - genetics.

Neoplasms - drug therapy.

Cancer Vaccines.

Inventions.

Immunosuppression.

Myeloma Proteins.

Neoplasm Metastasis - prevention & control.

Inflammation - drug therapy.

Drug Therapy.

Autoimmune Diseases.

Inflammation.

Fibrosis.

Kupffer Cells.

Liver Cirrhosis.

Heart.

Mucins.

Eye Diseases.

Wound Healing.

American Chemical Society, sponsoring body.