Contents: What is pain?
How much pain is someone suffering?
What is the use of pain?
Pain pathways
Types of pain (Nociceptive, Inflammatory, Neuropathic, mixed)
Primary erythromelalgia
Mutations in SCN9A cause erythromelalgia
Voltage-gated ion channels
Paroxysmal extreme pain disorder (familial rectal pain)
Mutations in SCN9A cause PEPD
Congenital insensitivity to pain
SCN9A gene map
Electrical activity of wild type versus mutant constructs
Low-copy number vector = pcDNA3JC
Exon 6 splice variants
Neuropathies HSANs
Rita Levi Montalcini
TRKA signalling
Hereditary autonomic and sensory neuropathy type 4 (HSAN4)
HSAN5
NGFB
Familial dysautonomia
Treatment of pain
Mendelian disorders of pain ; Update talk: Congenital insensitivity to pain
Genetic pain loss disorders and associated mutations
Hereditary sensory neuropathy
Hereditary sensory and autonomic neuropathy
FAAH-OUT-associated pain insensitivity
Mutated genes as potential analgesic drug targets
Painful genetic disorders.