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Abeta toxicity 1
Author
Title
Abeta toxicity 1 [electronic resource] / Colin L. Masters.
Published
London : Henry Stewart Talks, 2011.
Physical Description
1 online resource (1 streaming video file (54 min.) : color, sound).
Local Notes
Access is available to the Yale community.
Notes
Animated audio-visual presentation with synchronized narration.
Title from publisher's website (viewed January 2012).
Access and use
Access restricted by licensing agreement.
Variant and related titles
Title from title frames: Aβ toxicity, Part I
Abeta toxicity, Part I
Henry Stewart talks.
Format
Images / Online / Video & Film
Language
English
Added to Catalog
September 17, 2024
Series
Alzheimer's disease : neurobiology, pathology and treatment,
Drug discovery and development in the neurosciences,
Contents
Contents: The amyloid plaque
Impact of delaying onset of AD
The amyloidocentric theory of Alzheimer's disease
Compelling evidence for the Abeta theory of AD
Delay onset of AD by 5 years
The best target for a disease-modifying drug
APP structure and domains
Iron-export ferroxidase activity of beta-amyloid precursor protein
Age at onset correlates with Abeta isoforms
Activation of PS1
Abeta amyloid
The mechanism of neurodegeneration
Abeta metal binding modes
Current working model of Abeta toxicity
Abeta amyloid protein: current model consistent with EXAFS
Metal-protein attenuating compound (MPAC) with moderate affinity for metals
Clioquinol (CQ, PBT1) the prototypic MPAC
PBT2: SAR based on rational drug design
CQ (PBT1) vs. PBT2
Alzheimer's disease Abeta-directed therapeutics in clinical development: drugs and biologics
Phase II results of Abeta targeting AD modifying drugs.
Publisher's number
2957 Henry Stewart Talks
Subjects
Subjects (Medical)
Alzheimer Disease - drug therapy.
Alzheimer Disease - physiopathology.
Alzheimer Disease - therapy.
Amyloid beta-Peptides - toxicity.
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Citation
