Contents: Genetic screens for tumor suppressors in Drosophila
Identification of the Warts tumor suppressor
Identification of Hippo tumor suppressor and elucidation of the Hippo kinase cascade
Discovery of Yorkie as the nuclear effector of the Hippo pathway
Mechanism of Yorkie inactivation by phosphorylation
Conservation of the Hippo kinase cascade in mammals
The role of the Hippo pathway in mammalian organ size control and tumorigenesis.